N-(2,4-dinitrophenyl)-1,3-diaminopropane | 23920-00-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,4-dinitrophenyl)-1,3-diaminopropane
• 英文别名: N-(2,4-dinitrophenyl)-1,3-propanediamine；N-(2,4-Dinitrophenyl)-1,3-diaminopropan；N-(2.4-Dinitrophenyl)-1.3-diaminopropan；2,4-Dinitro-N-(3-aminopropyl)anilin；1,3-Propanediamine, N-(2,4-dinitrophenyl)-；N'-(2,4-dinitrophenyl)propane-1,3-diamine
• CAS: 23920-00-5
• 化学式: C₉H₁₂N₄O₄
• mdl: MFCD01140945
• 分子量: 240.219
• InChiKey: WQYQCAZWHZNUGX-UHFFFAOYSA-N

物化性质

• 熔点：
  87-88 °C
• 沸点：
  436.8±45.0 °C(Predicted)
• 密度：
  1.419±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,4-二硝基苯甲醚 、 1,3-丙二胺 以 苯 为溶剂， 反应 72.0h， 生成 N-(2,4-dinitrophenyl)-1,3-diaminopropane
  参考文献：
  名称：

  Lamm,B.; Palmertz,I., Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1976, vol. 30, p. 21 - 23

  摘要：

  DOI：

文献信息

• [EN] ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF<br/>[FR] DÉRIVÉS D'ANHYDRIDE ISATOÏQUE ET LEURS APPLICATIONS
  申请人：UNIV NORTH CAROLINA

  公开号：WO2015163952A1

  公开（公告）日：2015-10-29

  Isatoic anhydride derivatives having an N-substituent which includes a quaternary ammonium group are useful for labeling and/or functionalizing a target material and/or for coupling materials together. The isatoic anhydride derivatives of the present disclosure can be advantageously water soluble, easily prepared and purified. Isatoic anhydride derivatives useful in the present disclosure preferably have at least one chemically reactive group or at least one binding group or at least one detectable label. Anthranilate derivatives made from the isatoic anhydrides derivatives or otherwise and kits including the isatoic anhydride derivatives are also disclosed.

  异烟酰亚胺衍生物具有包括季铵基团的N-取代基，可用于标记和/或功能化目标材料和/或将材料耦合在一起。本公开的异烟酰亚胺衍生物可以具有优势的水溶性，易于制备和纯化。本公开中有用的异烟酰亚胺衍生物最好至少具有一个化学反应性基团或至少一个结合基团或至少一个可检测标记。从异烟酰亚胺衍生物制备的邻氨基苯甲酸酯衍生物或其他衍生物以及包括异烟酰亚胺衍生物的试剂盒也被公开。
• Solid-phase synthesis of cyclic polyamines
  作者：Pascal Bisegger、Nikolay Manov、Stefan Bienz

  DOI：10.1016/j.tet.2008.05.119

  日期：2008.8

  repetitive alkylations at benzylic N-atoms. Cyclizations at the resins were effected conventionally by direct intramolecular SN2 reactions between sulfonyl-protected terminal amino groups and primary alkyl bromides or by intramolecular Mitsunobu reactions between sulphonamides and primary alcohols. Particularly the latter transformation proved to be powerful for the construction of medium- as well as large-sized

  显示了一种基于固相化学合成环状多胺的方法。线性多胺是通过在苄基N原子上的重复烷基化作用从中心逐步在固相载体上合成的。在树脂环化物通常通过直接分子内小号实现Ñ 2个反应磺酰基-保护的末端氨基和伯烷基溴化物之间或由磺酰胺和伯醇之间的分子内的Mitsunobu反应。尤其是，后者的变形被证明对于构造中型和大型环非常有效。
• Chromatographic approach to the measurement of the interstrand distance for some chiral bonded phases
  作者：William H. Pirkle、Robin S. Readnour

  DOI：10.1021/ac00001a003

  日期：1991.1.1

  A series of homologus N,N'-bis(d,2-dinitrophenyl)-alpha,omega-diaminoalkanes (bis-DNP's) was chromatographed at various temperatures on pi-basic chiral stationary phases derived from N-(2-napthyl)alanine in order to determine the enthalpy and entropy of adsorption. The number of methylene groups in the bis-DNP's influences the ability of the terminal pi-acidic groups to interact simultaneously with neighboring strands of stationary phase, a process termed "bridging". When the number of methylene groups is optimal for bridging, the enthalpy of adsorption is most exothermic. The length of the bis-derivative required for optimal bridging is related to the interstrand distance. Optimal bridging occurs for the bis-DNP's having five methylene groups regardless of the extent of surface coverage of the silica for the surface coverage range investigated. This suggests that the strands are not randomly spaced on the silica, with interstrand distance being influenced only by surface coverage, but are instead clustered, the clusters having similar distributions of interstrand distances. Adsorption is more exothermic for phases of high surface coverages than for low. If interstrand spacing is independent of surface coverage but surface coverage affects the enthalpy of adsorption, t hen surface coverage must influence the cluster size, which then influences the average extent of solvation of a strand of bonded phase.
• Guanti, Giuseppe; Petrillo, Giovanni; Thea, Sergio, Journal of Chemical Research, Miniprint, 1982, # 10, p. 2764 - 2771
  作者：Guanti, Giuseppe、Petrillo, Giovanni、Thea, Sergio、Pero, Francesca

  DOI：——

  日期：——
• DEL CIMA F.; PIETRA F., J. HETEROCYCL. CHEM. <JHTC-AD>, 1975, 12, NO 4, 767-769
  作者：DEL CIMA F.、 PIETRA F.

  DOI：——

  日期：——