2-(3,5-dichlorophenylthio)aniline | 1375830-03-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-(3,5-dichlorophenylthio)aniline
• 英文别名: 2-(3,5-Dichlorophenyl)sulfanylaniline；2-(3,5-dichlorophenyl)sulfanylaniline
• CAS: 1375830-03-7
• 化学式: C₁₂H₉Cl₂NS
• 分子量: 270.182
• InChiKey: DZBYTHSGWVDSAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯并噻唑 、 3,5-二氯碘苯 在 四丁基氢氧化铵 、 水 、 copper(l) chloride 作用下， 反应 12.0h， 以85%的产率得到2-(3,5-dichlorophenylthio)aniline
  参考文献：
  名称：

  Unexpectedly ligand-free copper-catalyzed C–S cross-coupling of benzothiazole with aryl iodides in aqueous solution

  摘要：

  A novel synthetic protocol for 2-aminophenyl sulfide derivatives via the reactions of benzothiazole with aryl iodides was reported for the first time. The reactions were catalyzed by CuCl with tetrabutylammonium hydroxide as the base and water as the solvent without ligand at 50 degrees C or room temperature. A variety of aryl iodides underwent the C-S cross-coupling reaction with benzothiazole to afford smoothly the corresponding products in excellent yield. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.04.004

文献信息

• Unexpectedly ligand-free copper-catalyzed C–S cross-coupling of benzothiazole with aryl iodides in aqueous solution
  作者：Yi-Si Feng、Hong-Xia Qi、Wei-Cheng Wang、Yu-Feng Liang、Hua-Jian Xu

  DOI：10.1016/j.tetlet.2012.04.004

  日期：2012.6

  A novel synthetic protocol for 2-aminophenyl sulfide derivatives via the reactions of benzothiazole with aryl iodides was reported for the first time. The reactions were catalyzed by CuCl with tetrabutylammonium hydroxide as the base and water as the solvent without ligand at 50 degrees C or room temperature. A variety of aryl iodides underwent the C-S cross-coupling reaction with benzothiazole to afford smoothly the corresponding products in excellent yield. (C) 2012 Elsevier Ltd. All rights reserved.