5-Hydroxyphthalazine-1,4-dione | 7607-80-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5-Hydroxyphthalazine-1,4-dione
• CAS: 7607-80-9
• 化学式: C₈H₄N₂O₃
• 分子量: 176.13
• InChiKey: HVCMEHKGXSJATL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• USE OF CYCLIC BIOISOSTERES OF PURINE SYSTEM DERIVATIVES FOR THE TREATMENT OF DISEASES CAUSED BY DISORDERS OF NITRERGIC AND DOPAMINERGIC SYSTEMS
  申请人：Zhilov, Valery Khazhmuratovich

  公开号：EP1655028A2

  公开（公告）日：2006-05-10

  The invention relates to application of compounds having a general structural formula: where R= Li, Na, K, R1 = -H, -NH2, -Br, -Cl, -OH, -COOH, B = -N=, -CH=, Z = -CH= , -N=, A = -N= at B = -N= , Z = -CH-, A=-CH= at B = -N= , Z=-CH-, A = -CH= at B = -N= , Z = -N=, A = -CH= at B = -CH= , Z = -CH=, A = -CH= at B = -CH= , Z = -N= , and/or their pharmacologically acceptable salts as an active ingredient having appropriate activity with respect to nitrergic and/or dopaminergic systems, in a pharmaceutical composition as neuroprotector for improvement of the cognitive function and for normalization of psychophysiological status, as well as for treatment of a wide spectrum of psychological diseases, cardiovascular diseases, diseases caused by substance abuse, and diseases caused by a hyperactive immune system in mammals including human beings.

  本发明涉及具有一般结构式的化合物的应用： 其中 R= Li、Na、K R1 = -H、-NH2、-Br、-Cl、-OH、-COOH、 B = -N=，-CH=，Z = -CH= ，-N=、 A=-N=，B=-N=，Z=-CH-、 A=-CH= at B = -N= , Z=-CH-、 A = -CH= at B = -N= , Z = -N=、 A = -CH= at B = -CH= , Z = -CH=、 A = -CH= at B = -CH= , Z = -N= 、 和/或它们的药理学上可接受的盐类作为活性成分，在硝酸能和/或多巴胺能系统方面具有适当的活性，在药物组合物中作为神经保护剂，用于改善认知功能，使心理生理状态正常化，以及治疗包括人类在内的哺乳动物的各种心理疾病、心血管疾病、药物滥用引起的疾病和免疫系统过度活跃引起的疾病。
• CYCLIC BIOISOSTERS OF PURINE SYSTEM DERIVATIVES AND A PHARMACEUTICAL COMPOSITION BASED THEREON
  申请人：Zhilov, Valery Khazhmuratovich

  公开号：EP1655301A1

  公开（公告）日：2006-05-10

  The invention relates to cyclic bioisosteres of derivatives of a purine system having a general structural formula R1 = -H, -NH2, -Br, -C1, -OH, -COOH, B = -N=, -CH=, Z = -CH=, -N=, A = -N= at B = -N=, Z = -CH-, A = -CH= at B = -N=, Z = -CH-, A = -CH= at B = -N=, Z = -N=, A = -CH= at B = -CH=, Z = -CH=, A = -CH= at B = -CH=, Z = -N= , and their pharmacologically acceptable salts having a normalizing effect on endocellular processes, in particular, it is capable eliminating endocellular metabolic acidosis and capable of binding excessively formed free radicals, in particular, free-radical forms of oxygen, capable of normalizing the nitrergic mechanisms of the cells, and also capable of interreacting with adenosine-sensitive receptors on the membrane of non-nuclear cells and in nuclei-containing cells to decrease the aggregation of thrombocytes. The compounds according to the invention have hepatoprotective effect and can be used for producing pharmaceutical compositions on their base.

  本发明涉及嘌呤系统衍生物的环状生物异斯特，其结构通式为 R1 = -H, -NH2, -Br, -C1, -OH, -COOH、 B = -N=，-CH=，Z = -CH=，-N=、 A = -N= at B = -N=, Z = -CH-、 A = -CH= at B = -N=, Z = -CH-、 A = -CH= at B = -N=, Z = -N=、 A = -CH= at B = -CH=，Z = -CH=、 A = -CH= at B = -CH=, Z = -N= 、 及其药理上可接受的盐类，对细胞内过程具有正常化作用，特别是能消除细胞内代谢性酸中毒，能结合过多形成的自由基，特别是氧的自由基形式，能使细胞的硝化机制正常化，还能与无核细胞膜上和含核细胞膜上的腺苷敏感受体相互作用，减少血小板的聚集。本发明的化合物具有保肝作用，可用于生产以其为基础的药物组合物。
• Use of cyclic bioisosteres of purine system derivatives for the treatment of diseases caused by disorders of nitrergic and dopaminergic systems
  申请人：Zhilov, Valery Khazhmuratovich

  公开号：EP2074998A2

  公开（公告）日：2009-07-01

  The invention relates to application of compounds having a general structural formula: Li, Na, K, R1= -H, -NH2, -Br, -Cl, -OH, -COOH, B = -N=, -CH=, Z = -CH=, -N=, A = -N= at B = -N=, Z = -CH-, A = -CH= at B = -N=, Z = -CH-, A = -CH= at B = -N=, Z = -N=, A = -CH= at B -CH=, Z = -CH=, A = -CH= at B = -CH=, Z = -N= , and/or their pharmacologically acceptable salts as an active ingredient having appropriate activity with respect to nitrergic and/or dopaminergic systems, in a pharmaceutical composition as a neuroprotector for the improvement of the cognitive function and for normalization of the psychophysiological status, as well as for the treatment of a wide spectrum of psychological diseases, cardiovascular diseases, diseases caused by substance abuse, and diseases caused by a hyperactive immune system in mammals including human beings.

  本发明涉及具有一般结构式的化合物的应用： Li、Na、K、 R1=-H、-NH2、-Br、-Cl、-OH、-COOH、 B = -N=，-CH=，Z = -CH=，-N=、 A = -N= at B = -N=, Z = -CH-、 A = -CH= at B = -N=, Z = -CH-、 A = -CH= at B = -N=, Z = -N=、 A = -CH= at B -CH=, Z = -CH=、 A = -CH= at B = -CH=, Z = -N= 、 和/或它们的药理上可接受的盐类作为活性成分，在硝酸能和/或多巴胺能系统方面具有适当的活性，在药物组合物中作为神经保护剂，用于改善认知功能，使心理生理状态正常化，以及治疗包括人类在内的哺乳动物的各种心理疾病、心血管疾病、药物滥用引起的疾病和免疫系统亢进引起的疾病。
• Novel stabilized formulations for chemiluminescent assays
  申请人：——

  公开号：US20010046688A1

  公开（公告）日：2001-11-29

  A substrate having an extended shelf life for chemiluminescent detection and assaying is useful with enzyme-based probes as well as for immunoassays, DNA or RNA or protein detection and blotting. The substrate is a mixture of (a) a chemiluminescent compound, (b) an oxidant, (c) a stabilizer and (d) a buffer. The substrate may further include a chemiluminescent enhancer and a solubilizer. The substrate may be in an organic solvent or may be aqueous based.

  用于化学发光检测和化验的底物具有较长的保存期，可用于酶探针、免疫测定、DNA 或 RNA 或蛋白质检测和印迹。底物是由（a）化学发光化合物、（b）氧化剂、（c）稳定剂和（d）缓冲液组成的混合物。底物可进一步包括化学发光增强剂和增溶剂。基质可以是有机溶剂，也可以是水基。
• ENZYME-CATALYZED CHEMILUMINESCENT DETECTION OF PROTEINS AND NUCLEIC ACIDS USING HYDROXYARYL CYCLIC DIACYLHYDRAZIDE COMPOUNDS
  申请人：LUMIGEN, INC.

  公开号：EP0675968A1

  公开（公告）日：1995-10-11