N-(quinolin-8-yl)-4-bromo-1,8-naphthalimide | 1337988-65-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-(quinolin-8-yl)-4-bromo-1,8-naphthalimide
• 英文别名: 6-Bromo-2-quinolin-8-ylbenzo[de]isoquinoline-1,3-dione；6-bromo-2-quinolin-8-ylbenzo[de]isoquinoline-1,3-dione
• CAS: 1337988-65-4
• 化学式: C₂₁H₁₁BrN₂O₂
• 分子量: 403.235
• InChiKey: BVLQGWNLPCBGEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(quinolin-8-yl)-4-bromo-1,8-naphthalimide 、 正丁胺 以 二甲基亚砜 为溶剂， 以92%的产率得到N-(quinolin-8-yl)-4-butylamino-1,8-naphthalimide
  参考文献：
  名称：

  OFF-ON-OFF Fluorescence Switch with T-Latch Function

  摘要：

  A novel molecular system with characteristics of an OFF-ON-OFF fluorescence switch was designed to integrate the function of a T-latch. In detail, a receptor(1)-fluorophore-receptor(2) architecture was adopted to achieve fluorescence switching upon addition of protons.

  DOI：

  10.1021/ol202312n
• 作为产物：
  描述：

  8-氨基喹啉 、 4-溴-1,8-萘二甲酸酐 以 甲醇 为溶剂， 反应 24.0h， 以74%的产率得到N-(quinolin-8-yl)-4-bromo-1,8-naphthalimide
  参考文献：
  名称：

  OFF-ON-OFF Fluorescence Switch with T-Latch Function

  摘要：

  A novel molecular system with characteristics of an OFF-ON-OFF fluorescence switch was designed to integrate the function of a T-latch. In detail, a receptor(1)-fluorophore-receptor(2) architecture was adopted to achieve fluorescence switching upon addition of protons.

  DOI：

  10.1021/ol202312n

文献信息

• Multi-subunit vaccines to elicit both MHC- and CD1-restricted T cell responses
  申请人：Northwestern University

  公开号：US11202823B2

  公开（公告）日：2021-12-21

  Provided herein are subunit vaccine compositions comprising a nanocarrier and a lipid antigen, a peptide antigen or combinations thereof that elicit bother a CD1-restricted and an MHC-restricted T cell response in a subject. Methods for making and using the subunit vaccine compositions are also provided.

  本文提供的亚单位疫苗组合物包含纳米载体和脂质抗原、肽抗原或其组合，可在受试者体内引起 CD1 限制性和 MHC 限制性 T 细胞反应。此外，还提供了制造和使用亚单位疫苗组合物的方法。
• MULTI-SUBUNIT VACCINES TO ELICIT BOTH MHC- AND CD1-RESTRICTED T CELL RESPONSES
  申请人：Northwestern University

  公开号：US20200316186A1

  公开（公告）日：2020-10-08

  Provided herein are subunit vaccine compositions comprising a nanocarrier and a lipid antigen, a peptide antigen or combinations thereof that elicit bother a CD1-restricted and an MHC-restricted T cell response in a subject. Methods for making and using the subunit vaccine compositions are also provided.
• [EN] MULTI-SUBUNIT VACCINES TO ELICIT BOTH MHC- AND CD1-RESTRICTED T CELL RESPONSES<br/>[FR] VACCINS À PLUSIEURS SOUS-UNITÉS POUR INDUIRE DES RÉPONSES DE LYMPHOCYTES T RESTREINTES À LA FOIS PAR LE CMH ET CD1
  申请人：UNIV NORTHWESTERN

  公开号：WO2020206307A1

  公开（公告）日：2020-10-08

  Provided herein are subunit vaccine compositions comprising a nanocarrier and a lipid antigen, a peptide antigen or combinations thereof that elicit bother a CD1 -restricted and an MHC-restricted T cell response in a subject. Methods for making and using the subunit vaccine compositions are also provided.
• OFF-ON-OFF Fluorescence Switch with T-Latch Function
  作者：Vânia F. Pais、Patricia Remón、Daniel Collado、Joakim Andréasson、Ezequiel Pérez-Inestrosa、Uwe Pischel

  DOI：10.1021/ol202312n

  日期：2011.10.21

  A novel molecular system with characteristics of an OFF-ON-OFF fluorescence switch was designed to integrate the function of a T-latch. In detail, a receptor(1)-fluorophore-receptor(2) architecture was adopted to achieve fluorescence switching upon addition of protons.