1-(2-(3,4-Dichlorophenoxy)-5-fluorophenyl)-N-methylmethanamine hydrochloride | 289716-93-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-(3,4-Dichlorophenoxy)-5-fluorophenyl)-N-methylmethanamine hydrochloride
• 英文别名: 1-[2-(3,4-dichlorophenoxy)-5-fluorophenyl]-N-methylmethanamine;hydrochloride
• CAS: 289716-93-4
• 化学式: C14H13Cl3FNO
• 分子量: 336.6
• InChiKey: BXBKNFSQKDGBOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.07
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  21.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Osmotic delivery system
  申请人：——

  公开号：US20030175346A1

  公开（公告）日：2003-09-18

  An osmotic pharmaceutical tablet is described which comprises a single-layer compressed core surrounded by a water permeable layer having a passageway. The single-layer core contains (i) a non-ripening drug having a solubility per dose less than about 1 mL −1 , (ii) about 2.0% to about 20% by weight of a hydroxyethylcellulose having a weight-average, molecular weight from about 300,000 to about 2,000,000, and (iii) an osmagent.

  描述了一种渗透性制药片，其包括一个被可渗透水层包围的单层压缩核心，该可渗透水层具有一个通道。单层核心包含（i）一种每剂溶解度小于约1 mL-1的非成熟药物，（ii）约2.0％至约20％重量的羟乙基纤维素，其重量平均分子量约为300,000至2,000,000，以及（iii）渗透剂。
• OSMOTIC DELIVERY SYSTEM
  申请人：Pfizer Products Inc.

  公开号：EP1469826B1

  公开（公告）日：2006-11-22
• [EN] OSMOTIC DELIVERY SYSTEM<br/>[FR] SYSTEME DE DISTRIBUTION OSMOTIQUE
  申请人：PFIZER PROD INC

  公开号：WO2003063823A2

  公开（公告）日：2003-08-07

  An osmotic pharmaceutical tablet is described which comprises a single-layer compressed core surrounded by a water permeable layer having a passageway. The single-layer core contains (i) a non-ripening drug having a solubility per dose less than about 1 mL-1, (ii) about 2.0% to about 20% by weight of a hydroxyethylcellulose having a weight-average, molecular weight from about 300,000 to about 2,000,000, and (iii) an osmagent.