Methanamine, N-[(2-methylphenyl)methylene]-, (E)- | 53699-35-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methanamine, N-[(2-methylphenyl)methylene]-, (E)-
• 英文别名: o-tolualdehyde N-methylimine
• CAS: 53699-35-7
• 化学式: C₉H₁₁N
• 分子量: 133.193
• InChiKey: QIHXQRVPVMCYEO-JXMROGBWSA-N

物化性质

• 沸点：
  210.5±19.0 °C(Predicted)
• 密度：
  0.87±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.04
• 重原子数：
  10.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  12.36
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  N,N-二乙基-2-甲基苯甲酰胺 、 Methanamine, N-[(2-methylphenyl)methylene]-, (E)- 在 lithium diisopropyl amide 作用下， 生成 2-Methyl-3-o-tolyl-3,4-dihydro-2H-isoquinolin-1-one
  参考文献：
  名称：

  Synthesis of 3-substituted and 3,4-disubstituted 3,4-dihydro-1(2H)-isoquinolones by condensation of lithiated N,N-diethyl-o-toluamide with imines

  摘要：

  DOI：

  10.1021/jo00233a013
• 作为产物：
  描述：

  2-甲基苯甲醛 、 甲胺 反应 15.0h， 以90%的产率得到Methanamine, N-[(2-methylphenyl)methylene]-, (E)-
  参考文献：
  名称：

  Syntheses of polycyclic ring systems based on the new generation of o-quinodimethanes

  摘要：

  DOI：

  10.1021/ja00390a036

文献信息

• AGGREGATION-INDUCED EMISSION LUMINOGENS FOR METAL ION DETECTION
  申请人：TANG Benzhong

  公开号：US20130059392A1

  公开（公告）日：2013-03-07

  Pyridine-containing polyenes and their applications as metal ion sensors. These polyenes are practically nonluminescent in the solution state but become highly emissive as nanoparticle suspensions in aqueous solutions or thin films in the solid state, due to aggregation-induced emission (AIE). The nanoaggregates of these compounds can work as “turn-off” fluorescent chemosensors for metal ions and display different fluorescence responses to various metal ions. For example, a characteristic red shift in the emission spectra is observed with a terpyridine-containing luminogen in the presence of Zn 2+ . However, the terpyridine-containing luminogen displays a magenta color upon selectively binding with Fe 2+ . This allows easy identification of both Zn 2+ and Fe 2+ ions in aqueous media. The function of the polyenes can be easily tuned by altering the substituent groups. Due to their AIE properties, these polyenes can be used in aqueous solutions and in solid substrates for metal sensing.

  含吡啶基的聚烯烃及其作为金属离子传感器的应用。这些聚烯烃在溶液状态下几乎不发光，但当作为纳米颗粒悬浮液存在于水溶液中或以薄膜形式存在于固态中时，由于聚集诱导发光（AIE）而变得高度发光。这些化合物的纳米聚集体可以作为金属离子的“关闭”荧光化学传感器，并对各种金属离子显示不同的荧光响应。例如，在存在Zn2+时，富含三吡啶的发光剂的发射光谱中观察到特征性的红移。然而，当与Fe2+选择性结合时，富含三吡啶的发光剂显示品红色。这使得在水介质中轻松识别Zn2+和Fe2+离子成为可能。通过改变取代基，可以轻松调节聚烯烃的功能。由于其AIE特性，这些聚烯烃可用于水溶液和固体基质中的金属传感。
• (PYRROLIDIN-2-YL)PHENYL DERIVATIVES
  申请人：Grove Simon James Anthony

  公开号：US20100113493A1

  公开（公告）日：2010-05-06

  The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula I wherein R 1 is (C 1-4 )alkyl, halo(C 1-4 )alkyl, (C 1-4 )alkyloxy, or halo(C 1-4 )alkyloxy; R 2 is H, (C 1-4 )alkyl, halo(C 1-4 )alkyl, (C 1-4 )alkyloxy, halo(C 1-4 )alkyloxy or halogen; R 3 is H, (C 1-4 )alkyl or halo(C 1-4 )alkyl; R 4 is H, (C 1-4 )alkyl or halo(C 1-4 )alkyl; R 5 is H, (C 1-4 )alkyl or halo-(C 1-4 )-alkyl; or R 4 and R 5 , when bonded to the same carbon atom, can together with the carbon atom form a spiro(C 3-6 )cycloalkyl group, optionally substituted with halogen; R 6 is H, (C 1-4 )alkyl, halo(C 1-4 )alkyl, (C 1-4 )alkyloxy, halo(C 1-4 )alkyloxy or halogen; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these (pyrrolidin-2-yl)phenyl derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain.

  该发明涉及具有通式I的（吡咯啉-2-基）苯基衍生物，其中R1为（C1-4）烷基、卤代（C1-4）烷基、（C1-4）烷氧基或卤代（C1-4）烷氧基；R2为H、（C1-4）烷基、卤代（C1-4）烷基、（C1-4）烷氧基、卤代（C1-4）烷氧基或卤素；R3为H、（C1-4）烷基或卤代（C1-4）烷基；R4为H、（C1-4）烷基或卤代（C1-4）烷基；R5为H、（C1-4）烷基或卤代（C1-4）烷基；或者当R4和R5与同一碳原子结合时，它们可以与碳原子一起形成一个可选择地取代卤素的螺环（C3-6）环烷基基团；R6为H、（C1-4）烷基、卤代（C1-4）烷基、（C1-4）烷氧基、卤代（C1-4）烷氧基或卤素；或其药学上可接受的盐，以及含有这些（吡咯啉-2-基）苯基衍生物的药物组合物，以及这些（吡咯啉-2-基）苯基衍生物用于治疗疼痛，如神经痛或炎症性疼痛。
• NOVEL PROCESS FOR PREPARATION OF OPTICALLY PURE AND OPTIONALLY SUBSTITUTED 2-(1-HYDROXY-ALKYL)-CHROMEN-4-ONE DERIVATIVES AND THEIR USE IN PREPARING PHARMACEUTICALS
  申请人：Rhizen Pharmaceutical SA

  公开号：US20150087699A1

  公开（公告）日：2015-03-26

  The present invention relates to compounds useful as pharmaceutical intermediates, to processes for preparing the intermediates, to intermediates used in the processes, and to the use of the intermediates in the preparation of pharmaceuticals. In particular, the present invention concerns enantiomerically pure optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives represented by formula (IA) and (IB), processes for preparing the alcohol derivatives and their use in preparing pharmaceuticals.

  本发明涉及作为药物中间体有用的化合物，用于制备中间体的过程，用于这些过程中使用的中间体，以及在制备药物中使用这些中间体。具体来说，本发明涉及对映纯的可选取代的2-(1-羟基-烷基)-香豆素衍生物，其表示为式（IA）和（IB），制备醇衍生物的过程以及它们在制备药物中的使用。
• PROCESS FOR PREPARATION OF OPTICALLY PURE AND OPTIONALLY SUBSTITUTED 2-(1-HYDROXY-ALKYL)-CHROMEN-4-ONE DERIVATIVES AND THEIR USE IN PREPARING PHARMACEUTICALS
  申请人：Rhizen Pharmaceuticals SA

  公开号：US20170266196A1

  公开（公告）日：2017-09-21

  The present invention relates to compounds useful as pharmaceutical intermediates, to processes for preparing the intermediates, to intermediates used in the processes, and to the use of the intermediates in the preparation of pharmaceuticals. In particular, the present invention concerns enantiomerically pure optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives represented by formula (IA) and (IB), processes for preparing the alcohol derivatives and their use in preparing pharmaceuticals.

  本发明涉及用作制药中间体的化合物，制备中间体的过程，用于过程的中间体以及中间体在制备制药品中的应用。特别地，本发明涉及旋光纯的可选取代的2-(1-羟基-烷基)-香豆素衍生物，其化学式为（IA）和（IB），制备醇衍生物的过程以及它们在制备制药品中的应用。
• Synthetic studies on the lithiated toluamide-imine cycloaddition route to (.+-.)-corydalic acid methyl ester
  作者：Robin D. Clark、Jahangir

  DOI：10.1021/jo00266a033

  日期：1989.3