1-(2-Hydroxyethyl)-3-methyl-1H-pyrrole-2,5-dione | 143659-02-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(2-Hydroxyethyl)-3-methyl-1H-pyrrole-2,5-dione
• 英文别名: 1-(2-hydroxyethyl)-3-methylpyrrole-2,5-dione
• CAS: 143659-02-3
• 化学式: C₇H₉NO₃
• 分子量: 155.15
• InChiKey: KHKNFKNBERMAAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Succinimide and maleimide derivatives and their use as topoisomerase II catalytic inhibitors
  申请人：Topo Target ApS

  公开号：US20030032625A1

  公开（公告）日：2003-02-13

  Maleimide and succinimide derivatives were found to be effective topoisomerase II catalytic inhibitors. Due to this property, the maleimide and succinimide derivatives were investigated for their use as cytostatic agents and thus in the treatment of cancer. The compounds of the invention can be used in combination treatments with other cytostatic agents, such as topoisomerase II poisons. The maleimide and succinimide derivatives, due to their effective topoisomerase II catalytic inhibitory activity, are also useful as extravasation agents, such as upon administration of a topoisomerase II poison.

  Maleimide和succinimide衍生物被发现是有效的拓扑异构酶II催化抑制剂。由于这种特性，对maleimide和succinimide衍生物进行了研究，以评估它们作为细胞静止剂并在癌症治疗中的应用。该发明的化合物可与其他细胞静止剂（如拓扑异构酶II毒素）联合治疗。由于其有效的拓扑异构酶II催化抑制活性，maleimide和succinimide衍生物还可用作逸出剂，例如在给予拓扑异构酶II毒素后。
• SUCCINIMIDE AND MALEIMIDE DERIVATIVES AND THEIR USE AS TOPOISOMERASE II CATALYTIC INHIBITORS
  申请人：Jensen Buhl Peter

  公开号：US20070196360A1

  公开（公告）日：2007-08-23

  Maleimide and succinimide derivatives were found to be effective topoisomerase II catalytic inhibitors. Due to this property, the maleimide and succinimide derivatives were investigated for their use as cytostatic agents and thus in the treatment of cancer. The compounds of the invention can be used in combination treatments with other cytostatic agents, such as topoisomerase II poisons. The maleimide and succinimide derivatives, due to their effective topoisomerase II catalytic inhibitory activity, are also useful as extravasation agents, such as upon administration of a topoisomerase II poison.

  Maleimide和succinimide衍生物被发现是有效的拓扑异构酶II催化抑制剂。由于这种特性，研究了maleimide和succinimide衍生物作为细胞静止剂的用途，因此用于癌症的治疗。该发明的化合物可以与其他细胞静止剂，如拓扑异构酶II毒素，组合使用。由于其有效的拓扑异构酶II催化抑制活性，maleimide和succinimide衍生物也可用作外渗剂，例如在给予拓扑异构酶II毒素时。
• Citraconimide (co)polymers and curing with anionic catalyst
  申请人：Akzo Nobel N.V.

  公开号：EP0495545A1

  公开（公告）日：1992-07-22

  A process for the preparation of a (co)polymer containing at least one unit derived from a citraconimide by curing curable composition comprising at least one substituted or unsubstituted citraconimide and a sufficient amount of an anionic curing catalyst to convert at least 10% of the citraconic alkyl groups on the citraconimide units to alkylene bridges; at a temperature above the melting point of the citraconimide unit and the product of that curing process, are disclosed. The invention also relates to the cured oligomers and articles of manufacture embodying them. These novel, cured oligomers are thermoplastic and offer several advantageous properties.

  本发明公开了一种制备含有至少一个源自柠康亚胺的单元的（共）聚合物的工艺，其方法是在高于柠康亚胺单元熔点的温度下，固化可固化组合物，该组合物包括至少一个取代或未取代的柠康亚胺和足量的阴离子固化催化剂，以将柠康亚胺单元上至少 10%的柠康烷基转化为亚烷基桥。本发明还涉及固化后的低聚物及其制造品。这些新型固化低聚物是热塑性的，具有多种优势特性。
• CURABLE COMPOSITION COMPRISING INORGANIC OXIDE MICROPARTICLES THAT ARE SURFACE-MODIFIED WITH MALEIMIDE GROUPS
  申请人：TOAGOSEI CO., LTD.

  公开号：EP2371871A1

  公开（公告）日：2011-10-05

  To provide a curable composition that has excellent smoothness when a plastic substrate is coated therewith and dried, causes hardly any warp after curing or swarf when cutting, and has excellent scratch resistance, transparency, adhesion, and UV resistance and, furthermore, to provide an active energy beam-curable composition that can be cured without using a photopolymerization initiator or with the use of a small amount thereof. A curable composition containing a reaction product (A) obtained by reacting an alkoxysilane compound (a1) represented by Formula (1) below and inorganic oxide microparticles (a2) in the presence of water and an organic solvent.         (P-SiO3/2)1-a(P-Si(R0)O2/2)a(O1/2R3)z     (1) In Formula (1), P denotes a maleimide-containing group, R3 denotes a hydrogen atom or a monovalent organic group, R0 denotes a monovalent organic group, a is 0 or a positive number and satisfies 0 ≤ a < 1, and z is a positive number and satisfies 0.1 ≤ z ≤ 2.

  提供一种固化组合物，该组合物在涂覆塑料基材并干燥后具有极佳的平滑性，固化后几乎不会产生翘曲或切割时产生切屑，并且具有极佳的抗划伤性、透明度、粘附性和抗紫外线性，此外，还提供一种无需使用光聚合引发剂或只需使用少量引发剂即可固化的主动能光束固化组合物。 一种可固化组合物，其中含有一种反应产物 (A)，该反应产物是由下式 (1) 所代表的烷氧基硅烷化合物 (a1) 和无机氧化物微粒 (a2) 在水和有机溶剂存在下反应而得。 (P-SiO3/2)1-a(P-Si(R0)O2/2)a(O1/2R3)z (1) 在式(1)中，P 表示含马来酰亚胺的基团，R3 表示氢原子或一价有机基团，R0 表示一价有机基团，a 为 0 或正数且满足 0≤a <1，z 为正数且满足 0.1≤z ≤2。
• Polarizing plate and image display device including the same
  申请人：LG CHEM, LTD.

  公开号：US10353125B2

  公开（公告）日：2019-07-16

  The present disclosure relates to a polarizing plate including an adhesive layer, a primer layer and a polyethylene terephthalate film which are sequentially formed on at least one side of a polarizer, wherein the adhesive layer in the present disclosure is formed by an active energy ray-curable adhesive including a first epoxy compound of which a homopolymer has a glass transition temperature of 120° C. or higher, a second epoxy compound of which a homopolymer has a glass transition temperature of 60° C. or lower, and a cationic photopolymerization initiator, and wherein the primer layer is formed by a primer composition including one or more binder resins selected from the group consisting of polyester and polyvinyl alcohol-based resins, and one or more cross-linking agents selected from the group consisting of acrylic cross-linking agents, epoxy-based cross-linking agents and polyvinyl alcohol-based cross-linking agents.

  本公开涉及一种偏光板，包括粘合剂层、底涂层和聚对苯二甲酸乙二醇酯薄膜，它们依次形成于偏光板的至少一侧，其中，本公开中的粘合剂层由活性能量射线固化粘合剂形成，该粘合剂包括第一环氧化合物（其均聚物的玻璃化转变温度为120℃或更高）、第二环氧化合物（其均聚物的玻璃化转变温度为60℃或更低）和阳离子光聚合引发剂，其中，底涂层由底涂组合物形成，该底涂组合物包括一种或多种粘合剂树脂，该粘合剂树脂选自由聚酯和聚对苯二甲酸乙二醇酯组成的组。或更低的第二环氧化合物，以及阳离子光聚合引发剂，其中底漆层由底漆组合物形成，该底漆组合物包括选自由聚酯和聚乙烯醇基树脂组成的组中的一种或多种粘合剂树脂，以及选自由丙烯酸交联剂、环氧基交联剂和聚乙烯醇基交联剂组成的组中的一种或多种交联剂。