Pyridin-3-carbonsaeure-(2-cyan-ethylamid) | 1131-85-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Pyridin-3-carbonsaeure-(2-cyan-ethylamid)
• 英文别名: N-(2-cyano-ethyl)-nicotinamide；N-(2-Cyanoethyl)-3-pyridinecarboxamide；N-(2-cyanoethyl)pyridine-3-carboxamide
• CAS: 1131-85-7
• 化学式: C₉H₉N₃O
• mdl: MFCD16664313
• 分子量: 175.19
• InChiKey: AWGWEMCHJWLKEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene derivatives and related treatment methods
  申请人：Gruenenthal GmbH

  公开号：US20040192916A1

  公开（公告）日：2004-09-30

  Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene compounds and processes for their production, the use thereof for producing pharmaceutical compositions, pharmaceutical compositions containing these compounds and methods of treatment using these compounds.

  替代了1-氧杂-2,8-二氮杂螺[4,5]癸-2-烯化合物及其制备方法，其用于制备药物组合物，包含这些化合物的药物组合物以及使用这些化合物的治疗方法。
• Pyrazole-amides and -sulfonamides
  申请人：Atkinson N. Robert

  公开号：US20050049237A1

  公开（公告）日：2005-03-03

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazole-amides and -sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.

  本发明提供了一种通过抑制电压依赖性钠通道中的钠离子流来治疗疾病的化合物、组合物和方法。更具体地，本发明提供了吡唑酰胺和磺酰胺，以及其组合物和方法，这些化合物、组合物和方法对于治疗中枢或外周神经系统疾病特别是疼痛和慢性疼痛非常有用，通过阻止与所述疾病的发作或复发有关的钠通道。本发明的化合物、组合物和方法特别适用于通过抑制包括PN3亚基的通道中的离子流来治疗神经病理性或炎性疼痛。
• PYRAZOLE-AMIDES AND -SULFONAMIDES
  申请人：Atkinson N. Robert

  公开号：US20080064690A1

  公开（公告）日：2008-03-13

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazole-amides and -sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.

  本发明提供了一种通过抑制电压依赖性钠通道中的钠离子通量来治疗疾病的化合物、组合物和方法。更具体地，本发明提供了嘧唑酰胺和磺酰胺、组合物和方法，用于治疗中枢或外周神经系统障碍，特别是疼痛和慢性疼痛，通过阻断与指示条件的发生或复发有关的钠通道。本发明的化合物、组合物和方法特别适用于通过抑制包括PN3亚单位的通道中的离子通量来治疗神经病理性或炎症性疼痛。
• Substituted 4,5,6,7 -Tetrahydro-Isoxazolo[4,5-C]Pyridine Compounds and Use Thereof for Producing Medicaments
  申请人：Sundermann Corinna

  公开号：US20090076001A1

  公开（公告）日：2009-03-19

  The present invention relates to substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compound corresponding to formula I, methods for producing them, to medicaments containing these compounds, the use of these compounds for producing medicaments and related treatment methods

  本发明涉及替代的4,5,6,7-四氢异噁唑[4,5-c]吡啶化合物，其对应于式I，制备这些化合物的方法，含有这些化合物的药物，使用这些化合物制备药物和相关治疗方法。
• SUBSTITUIERTE 1-OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-EN-DERIVATE ALS ARZNEIMITTEL GEGEN SCHMERZ
  申请人：Grünenthal GmbH

  公开号：EP1401841B1

  公开（公告）日：2005-08-24