3-(phenylthio)-1H-1,2,4-triazole

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-(phenylthio)-1H-1,2,4-triazole
• 英文别名: 3-(Phenylthio)-1,2,4-Triazole；5-phenylsulfanyl-1H-1,2,4-triazole
• 化学式: C₈H₇N₃S
• 分子量: 177.23
• InChiKey: QWYURAKQRYZRSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-phenylthio-1-<2-(trimethylsilyl)ethoxy>methyl-1H-1,2,4-triazole 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以90%的产率得到3-(phenylthio)-1H-1,2,4-triazole
  参考文献：
  名称：

  Fugina, Natalie; Holzer, Wolfgang; Wasicky, Michael, Heterocycles, 1992, vol. 34, # 2, p. 303 - 314

  摘要：

  DOI：

文献信息

• Bimetallic BaMoO₄ nanoparticles for the C–S cross-coupling of thiols with haloarenes
  作者：Subhalaxmi Panda、Santosh Kumar Sahu、Pradyota Kumar Behera、Reba Panigrahi、Bamakanta Garnaik、Laxmidhar Rout

  DOI：10.1039/c9nj05581a

  日期：——

  disclosed new bimetallic BaMoO4 nanoparticles for the C–S cross-coupling reaction. The C–S cross-coupling reaction of alkyl/aryl thiols with haloarenes was accomplished with high yields. The reaction has good functional group tolerance and selectivity. This is an efficient protocol for synthesizing the building blocks of pharmaceuticals containing C–S bonds. The catalyst is recyclable. The unactivated

  我们公开了用于C–S交叉偶联反应的新型双金属BaMoO 4纳米颗粒。烷基/芳基硫醇与卤代芳烃的C–S交叉偶联反应以高收率完成。该反应具有良好的官能团耐受性和选择性。这是合成包含C–S键的药物组成部分的有效协议。该催化剂是可回收的。未活化的溴和4-乙酰基氟代芳烃可以很好地偶联，从而以高收率得到硫醚。据信该反应通过氧化加成和还原消除来进行。
• Mild ligand-free Cu0-catalyzed chemoselective S-arylation of 2-mercaptoimidazole at low catalyst loading
  作者：Bryan Yong-Hao Tan、Yong-Chua Teo

  DOI：10.1016/j.tet.2016.08.085

  日期：2016.10

  2-mercaptoimidazole derivatives with a series of with differently substituted iodobenzenes and iodothiophenes at 100 °C is described. This method proceeds efficiently without ligands and at low catalyst loading (3 mol %), without the need for stringent inert conditions. Under optimized conditions, the S-arylated products were obtained in good yields of up to 90%.

  描述了一种温和的方法，用于在100°C下用Cu 0催化2-巯基咪唑衍生物与一系列不同取代的碘代苯和碘代噻吩的化学选择性C S交叉偶联。该方法无需配体且催化剂负载量低（3 mol％）即可高效进行，而无需严格的惰性条件。在优化的条件下，可以高达90％的高收率获得S-芳基化产物。
• Herbicidal triazole compounds and herbicidal compositions containing the
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US05147445A1

  公开（公告）日：1992-09-15

  Novel triazole compounds represented by the general formulas I and II, a process for producing novel triazole compounds of the general formula I from novel triazole compounds of the general formula II as starting materials, and herbicides that include novel triazole compounds of the general formula I: ##STR1## where R.sub.1 and R.sub.2 which may be the same or different each represents a lower alkyl, cycloalkyl, alkenyl or alkynyl group, or R.sub.1 and R.sub.2, when taken together with the nitrogen atom to which they are bonded, represent an azacycloalkane having 4-6 carbon atoms; A represents a group represented by one of the following formulas: ##STR2## (where X is a hydrogen atom or an optionally hydroxyl substituted lower alkyl, cycloalkyl, alkoxy, alkoxycarbonyl, alkylcarbonyl, phenoxy, benzyl or .alpha.-hydroxybenzyl group, a halogen, a nitro group, an amino group or trifluoromethyl group; R.sub.3 is a hydrogen atom or lower alkoxy; m is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and p and q are each 2, 3, 4 or 5).

  这是关于新型三唑化合物的专利申请，包括一般式I和II表示的新型三唑化合物，从一般式II表示的新型三唑化合物作为起始物质制备一般式I表示的新型三唑化合物的方法，以及包含新型三唑化合物的除草剂： 其中，R1和R2可能相同或不同，分别表示较低的烷基、环烷基、烯基或炔基，或当R1和R2连同它们所连接的氮原子一起表示具有4-6个碳原子的氮代环烷基；A表示以下公式之一所表示的基团： 其中，X是氢原子或选用的羟基取代的较低的烷基、环烷基、烷氧基、烷氧羰基、烷基羰基、苯氧基、苯甲基或α-羟基苯甲基基团，卤素、硝基、氨基或三氟甲基基团；R3是氢原子或较低的烷氧基；m为0、1、2、3或4；n为0、1或2；p和q分别为2、3、4或5。
• Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0240015A2

  公开（公告）日：1987-10-07

  Carbostyril derivatives and salts thereof represented by the general formula (1), including some known compounds, possess activities for inhibiting adhesion of thrombocytes. Some carbostyril derivatives having chemical structural formulas similar to those of carbostyril derivatives and salts thereof represented by the general formula (1) have been known in the prior art references, however above-mentioned pharmacological activities have not been known yet up to the date. Processes for preparing carbostyril derivatives offormu- la (1), a pharmaceutical composition containing them, or a salt thereof, as active ingredient, and their use in the preparation of a medicament for inhibiting adhesion of thrombocytes are also disclosed.

  通式(1)代表的羧基吡啶衍生物及其盐类，包括一些已知化合物，具有抑制血小板粘附的活性。 一些羧基吡啶衍生物的化学结构式与通式(1)代表的羧基吡啶衍生物及其盐类相似，在现有技术参考文献中已为人所知，但上述药理活性至今尚未为人所知。 本发明还公开了制备通式(1)代表的羧基吡啶衍生物、含有它们或其盐类作为活性成分的药物组合物的工艺，以及它们在制备抑制血小板粘附的药物中的用途。
• Novel triazole compounds, process for producing the same, and herbicidal compositions containing the same
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP0332133A1

  公开（公告）日：1989-09-13

  Novel triazole compounds represented by the general formulas I and II, a process for producing novel triazole compounds of the general formula I from novel triazole compounds of the general formula II as starting materials, and herbicides that include novel triazole compounds of the general formula I: where R1 and R2 which may be the same or different each represents a lower alkyl, cycloalkyl, alkenyl or alkynyl group, or R1 and R2, when taken together with the nitrogen atom to which they are bonded, represent an azacycloalkane having 4 - 6 carbon atoms; A represents a group represented by one of the following formulas: (where X is a hydrogen atom or an optionally hydroxyl substituted lower alkyl, cycloalkyl, alkoxy, alkoxycarbonyl, alkylcarbonyl, phenoxy, benzyl or a-hydroxybenzyl group, a halogen, a nitro group, an amino group or trifluoromethyl group; R3 is a hydrogen atom or lower alkoxy; m is 0, 1, 2, 3 or 4; n is 0, 1 or 2; and p and q are each 2, 3, 4 or 5).

  通式 I 和 II 所代表的新型三唑化合物，以通式 II 的新型三唑化合物为起始原料生产通式 I 的新型三唑化合物的工艺，以及包括通式 I 的新型三唑化合物的除草剂： 其中 R1 和 R2 可以相同或不同，各自代表低级烷基、环烷基、烯基或炔基，或者 R1 和 R2 与它们结合的氮原子一起代表具有 4-6 个碳原子的氮杂环烷； A 代表由下列公式之一表示的基团： (其中 X 是氢原子或任选被羟基取代的低级烷基、环烷基、烷氧基、烷氧羰基、烷基羰基、苯氧基、苄基或 a-羟基苄基、卤素、硝基、氨基或三氟甲基；R3 是氢原子或低级烷氧基；m 是 0、1、2、3 或 4；n 是 0、1 或 2；p 和 q 分别是 2、3、4 或 5）。