1,2-bis(bis(2-methylthiophenyl)phosphino)ethane | 99346-83-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1,2-bis(bis(2-methylthiophenyl)phosphino)ethane
• 英文别名: 1,2-ethanediyl-bis[bis(2-methylthiophenyl)phosphine]；Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]-；2-bis(2-methylsulfanylphenyl)phosphanylethyl-bis(2-methylsulfanylphenyl)phosphane
• CAS: 99346-83-5
• 化学式: C₃₀H₃₂P₂S₄
• 分子量: 582.796
• InChiKey: JXRFSPHGORBIOI-UHFFFAOYSA-N

物化性质

• 熔点：
  213-216 °C(Solv: ethanol (64-17-5); chloroform (67-66-3))
• 沸点：
  670.7±55.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,2-bis(bis(2-methylthiophenyl)phosphino)ethane 生成
  参考文献：
  名称：

  HILL, DAVID T.;JOHNSON, RANDALL K.;MIRABELLI, CHRISTOPHER K.

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2-双(二氯磷基)-乙烷 生成 1,2-bis(bis(2-methylthiophenyl)phosphino)ethane
  参考文献：
  名称：

  HILL, DAVID T.;JOHNSON, RANDALL K.;MIRABELLI, CHRISTOPHER K.

  摘要：

  DOI：

文献信息

• Carbonyl complexes of molybdenum and tungsten with functionalized diphosphines: X-ray crystal structure of [{W(CO)3}2{μ-P(C6H4SMe-2)2CH2CH2P(C6H4SMe-2)2}]
  作者：Mohammad F.M. Al-Dulaymmi、Peter B. Hitchcock、Raymond L. Richards

  DOI：10.1016/s0277-5387(00)86079-9

  日期：1991.1

  binuclear complexes [M(CO)3}2(μ-diphos)] (M = Mo or W; diphos = mtppm, mtppe or iptppe) have been prepared. Their binuclear structures are established by the X-ray structure of [W(CO)3}2(μ-mtppe)], in which each tungsten is ligated by three carbonyl groups in a facial arrangement with P,S,S ligation from the bridging mtppe ligand completing the octahedral geometry [average d(WS) 2.514(9), d (WP) 2.420(6)

  摘要制备了二膦桥联的双核络合物[M（CO）3} 2（μ-diphos）]（M = Mo或W； diphos = mtppm，mtppe或iptppe）。它们的双核结构是由[W（CO）3} 2（μ-mtppe）]的X射线结构建立的，其中每个钨被三个羰基基团以面部排列方式连接，P，S，S的连接方式为完成八面体几何构型的桥联mtppe配体[平均d（WS）2.514（9），d（WP）2.420（6）A]。桥接复合物[M（CO）4} 2（μ-dppmpe）]和[MBr2（CO）2} 2（μ-mtppe）]和单核化合物[M（CO）4（dbtpe）]和[还描述了MoBr 2（CO）2（mtppe）]。
• Bimetallic complexes of molybdenum and tungsten with functionalized diphosphines: X-ray crystal structure of [{W(CO)3}(μ-mtppe)]
  作者：Mohammed F.M. Al-Dulaymmi、Peter B. Hitchcock、Raymond L. Richards

  DOI：10.1016/s0277-5387(00)80681-6

  日期：1989.1

  The binuclear complexes [M(CO)3}2(μ-diphos)] (M = Mo or W; diphos = mtppm, mtppe or iptppe) (X-ray structure for M = W, diphos = mtppe), [M(CO)4}2 (μ-dppmpe)] and [MBr2(CO)2}2(μ-mtppe)], and the mononuclear compounds [M(CO)4(dbtpe)] and [MoBr2(CO)2(mtppe)] have been prepared.

  双核络合物[M（CO）3} 2（μ-diphos）]（M = Mo或W; diphos = mtppm，mtppe或iptppe）（M的X射线结构= W，diphos = mtppe），[ M（CO）4} 2（μ-dppmpe）和[MBr2（CO）2} 2（μ-mtppe）]，以及单核化合物[M（CO）4（dbtpe）]和[MoBr2（CO） 2（mtppe）]已经准备好了。
• Antitumor activity of bis(diphenylphosphino)alkanes, their gold(I) coordination complexes, and related compounds
  作者：Christopher K. Mirabelli、David T. Hill、Leo F. Faucette、Francis L. McCabe、Gerald R. Girard、Deborah B. Bryan、Blaine M. Sutton、Joan O. Leary Barus、Stanley T. Crooke、Randall K. Johnson

  DOI：10.1021/jm00395a004

  日期：1987.12

  inactive. Among dppe analogues, replacement of phenyl groups with ethyl or benzyl groups resulted in inactivity for both ligands and the corresponding gold complexes whereas substitution with cyclohexyl or heterocyclic ring systems yielded ligands and/or gold complexes with antitumor activity. Among substituted-phenyl dppe and dppe(AuCl)2 analogues, 3-fluoro, 4-fluoro, perdeuterio, 4-methylthio, and 2-methylthio

  描述了与双（二苯基膦基）乙烷（dppe）有关的双膦及其金配合物，在多种可移植肿瘤模型中具有活性。在第1-5天以最大耐受剂量（MTD）40μmol/ kg腹膜内给药时，dppe可重复产生ip P388白血病小鼠的寿命（ILS）100％。氯金（I）与dppe中的每种膦配位得到的复合物具有相似的活性，但剂量水平比dppe低得多。金（I）配合物的MTD为7μmol/ kg。在dppe的其他金属络合物中，Au（III）络合物具有活性（大于50％ILS），而Ag（I），Ni（II），Pt（II），Pd（II）和Rh（I）络合物具有活性。不活跃。在dppe类似物中，用乙基或苄基取代苯基会导致配体和相应的金络合物均失活，而用环己基或杂环系统取代会产生具有抗肿瘤活性的配体和/或金络合物。在取代的苯基dppe和dppe（AuCl）2类似物中，3-氟，4-氟，氘代，4-甲硫基和2-甲硫基类似物是有活性的。4-甲
• Antitumor pharmaceutical compositions and compounds for treating tumors employing (alpha-omega-bis(disubstitutedphosphino)-hydrocarbon) digold(I), digold(III), disilver(I), and dicopper(I) derivatives
  申请人：SMITHKLINE BECKMAN CORPORATION

  公开号：EP0151046A2

  公开（公告）日：1985-08-07

  Pharmaceutical compositions and compounds for treating tumors by administering an effective tumor cell growth-inhibiting amount of a [a, ω-bis (disubstituted phosphino)hydrocarbon] digold(I), digold(III), disilver(I) or dicop- per(I) derivative to an animal afflicted by such tumor cells, are described.

  本文描述了通过向患有肿瘤细胞的动物施用有效抑制肿瘤细胞生长的[a, ω-双（二取代膦）烃]二金（I）、二金（III）、二银（I）或二过（I）衍生物来治疗肿瘤的药物组合物和化合物。
• Mono- and bi-nuclear complexes of rhodium with functionalised diphosphine ligands
  作者：Mohammad F. M. Al-Dulaymmi、Adrian Hills、Peter B. Hitchcock、David L. Hughes、Raymond L. Richards

  DOI：10.1039/dt9920000241

  日期：——

  Treatment of [RhCl(PPh3)3] with R2PCH2CH2PR2 (R = C6H4SMc-2 or C6H4SPr 2) gives the ionic complexes [Rh(R2PCH2CH2PR2)]Cl A. When R = C7H4NS (benzothiazolyl) or C8H7N7 (N-methyl-bonzimidazolyl), however, the partially substituted complex [RhCl(PPh3)(R2PCH2CH2PR2)] B result. Treatment of B (R = C7H4NS) with CHCl3 results in oxidation and disproportionation to the salt \ (RhCl)2-(mu-dbtpe)2][RhCl4(dbtpe)]2 C [dbtpe = (C7H6NS)2PCH2CH2P(SNC7H4)2]. X-ray diffraction analysis of C shows the cation to have a structure with a P-P chelated dbtpe ligand on each RhCl unit spanning the two metals by P,N ligation. The anion has regular octahedral co-ordination. Reaction of dbtpe with [RhCl(cod)}2] (cod - cycloocta-1,5-diene) or [RhCl(CO)2}2\ gives [(RhCl)2(mu-dbtpe)2] D which also has two P-P chelated RhCl units linked by P,N ligation, as shown by an X-ray crystal structure analysis. Full spectroscopic details are given for these compounds and their possible inter-relationship is discussed.