1-Oxido-1,2-dithiane-4,5-diyl bis(4-methylbenzenesulfonate)

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Oxido-1,2-dithiane-4,5-diyl bis(4-methylbenzenesulfonate)
• 英文别名: [5-(4-methylphenyl)sulfonyloxy-1-oxodithian-4-yl] 4-methylbenzenesulfonate
• 化学式: C₁₈H₂₀O₇S₄
• 分子量: 476.6
• InChiKey: ZBQZGIZULLRIKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  165
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• Tethering cysteine residues using cyclic disulfides
  申请人：Brandeis University

  公开号：US10689639B2

  公开（公告）日：2020-06-23

  Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization.

  本文描述了用于拴系蛋白质的化合物和方法。例如，描述了蛋白质（包括 SOD1 和 DJ-1）的二聚体，其中二聚体是通过环状二硫连接体将第一单体上的半胱氨酸与第二单体上的半胱氨酸共价键合而形成的。共价连接的二聚体具有更高的稳定性。
• EP2920196B1
  申请人：——

  公开号：EP2920196B1

  公开（公告）日：2021-03-31
• Tethering Cysteine Residues Using Cyclic Disulfides
  申请人：BRANDEIS UNIVERSITY

  公开号：US20150284478A1

  公开（公告）日：2015-10-08

  Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization.
• TETHERING CYSTEINE RESIDUES USING CYCLIC DISULFIDES
  申请人：Brandeis University

  公开号：US20160333336A1

  公开（公告）日：2016-11-17

  Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization.
• US9428589B2
  申请人：——

  公开号：US9428589B2

  公开（公告）日：2016-08-30