5-(3-Carboxy-5-chloro-4-hydroxy-benzoyl)-3-chloro-2-hydroxy-benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(3-Carboxy-5-chloro-4-hydroxy-benzoyl)-3-chloro-2-hydroxy-benzoic acid
• 英文别名: 5-(3-carboxy-5-chloro-4-hydroxybenzoyl)-3-chloro-2-hydroxybenzoic acid
• 化学式: C₁₅H₈Cl₂O₇
• 分子量: 371.1
• InChiKey: HNXQOJNARIRRDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Heterobifunctional pan-selectin inhibitors
  申请人：GlycoMimetics, Inc.

  公开号：EP2264043A1

  公开（公告）日：2010-12-22

  Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise particular glycomimetics alone or linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).

  本文提供了用于调节由选择素结合介导的体外和体内过程的化合物和方法。更具体地说，描述了选择素调节剂及其用途，其中调节（例如，抑制或增强）选择素介导的功能的选择素调节剂包括单独的或与称为 BASAs（苄基氨基磺酸）的一类化合物的成员或称为 BACAs（苄基氨基羧酸）的一类化合物的成员相连的特定拟糖体。
• HETEROBIFUNCTIONAL PAN-SELECTIN INHIBITORS
  申请人：GlycoMimetics, Inc.

  公开号：EP1934236B1

  公开（公告）日：2012-11-21
• Heterobifunctional compounds for selectin inhibition
  申请人：Magnani John L.

  公开号：US20090036386A1

  公开（公告）日：2009-02-05

  Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise glycomimetics linked to a compound, for example a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
• MULTIMERIC PAN-SELECTIN ANTAGONISTS
  申请人：GLYCOMIMETICS, INC.

  公开号：US20220220144A1

  公开（公告）日：2022-07-14

  Compounds, compositions, and methods for modulating in vitro and in vivo processes mediated by selectin binding are described herein. For example, multimeric selectin modulators and their use are described, wherein the multimeric selectin modulators comprise a glycomimetic linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
• US8633303B2
  申请人：——

  公开号：US8633303B2

  公开（公告）日：2014-01-21