Methyl 2-((2,5-dihydroxybenzyl)amino)benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2-((2,5-dihydroxybenzyl)amino)benzoate
• 英文别名: methyl 2-[(2,5-dihydroxyphenyl)methylamino]benzoate
• 化学式: C₁₅H₁₅NO₄
• 分子量: 273.28
• InChiKey: HOYMVLYORHKZIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS<br/>[FR] LA PROTECTION DE TISSUS ET DE CELLULES CONTRE LES EFFETS CYTOTOXIQUE D'UN RAYONNEMENT IONISANT PAR DES INHIBITEURS ABL
  申请人：UNIV TEMPLE

  公开号：WO2005065074A2

  公开（公告）日：2005-07-21

  Pre-treatment with one or more compounds of formula (I), as described herein, protects normal cells from the toxic side effects of ionizing radiation. Administration of one or more radioprotective compounds of formula I to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of one or more compounds of formula I allows for the safe increase the dosage of anticancer radiation. Amelioration of toxicity following inadvertent radiation exposure may also be mitigated with administration of one or more compounds of formula (I).