N-(3,4-methylenedioxybenzylideneamino)-N'-hydroxyguanidine tosylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,4-methylenedioxybenzylideneamino)-N'-hydroxyguanidine tosylate
• 英文别名: 2-(1,3-benzodioxol-5-ylmethylideneamino)-1-hydroxyguanidine;4-methylbenzenesulfonic acid
• 化学式: (x)C₇H₈O₃S*C₉H₁₀N₄O₃
• InChiKey: PJZAZUXDFXNADM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.451
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  164
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  胡椒醛 、 N-hydroxy-N'-aminoguanidine tosylate 以 甲醇 为溶剂， 生成 N-(3,4-methylenedioxybenzylideneamino)-N'-hydroxyguanidine tosylate
  参考文献：
  名称：

  Schiff bases of N-hydroxy-N′-aminoguanidines as antiviral, antibacterial and anticancer agents

  摘要：

  A series of Schiff bases of N-hydroxy-N-aminoguanidine tosylate (SB-HAG) were prepared and tested for their in vitro antitumoral, antiviral and antibacterial activities. Several compounds displayed a weak anticancer activity and an interesting activity against viruses.

  DOI：

  10.1016/0223-5234(94)90137-6

文献信息

• Schiff bases of N-hydroxy-N′-aminoguanidines as antiviral, antibacterial and anticancer agents
  作者：R Pignatello、A Panico、P Mazzone、MR Pinizzotto、A Garozzo、PM Fumeri

  DOI：10.1016/0223-5234(94)90137-6

  日期：1994.1

  A series of Schiff bases of N-hydroxy-N-aminoguanidine tosylate (SB-HAG) were prepared and tested for their in vitro antitumoral, antiviral and antibacterial activities. Several compounds displayed a weak anticancer activity and an interesting activity against viruses.