2-(4-Dimethylamino-phenyl)-4-hydroxy-4-methyl-6-oxo-cyclohexane-1,3-dicarboxylic acid diethyl ester

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(4-Dimethylamino-phenyl)-4-hydroxy-4-methyl-6-oxo-cyclohexane-1,3-dicarboxylic acid diethyl ester
• 英文别名: Diethyl 2-[4-(dimethylamino)phenyl]-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate
• 化学式: C₂₁H₂₉NO₆
• mdl: MFCD00521059
• 分子量: 391.464
• InChiKey: QUSPUJJUTGSQHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  93.1
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(4-Dimethylamino-phenyl)-4-hydroxy-4-methyl-6-oxo-cyclohexane-1,3-dicarboxylic acid diethyl ester 、 硫脲 在 乙醇 、 sodium ethanolate 作用下， 生成 5-(4-Dimethylamino-phenyl)-7-methyl-4-oxo-2-thioxo-2,3,4,4a,5,6-hexahydro-quinazoline-6-carboxylic acid ethyl ester
  参考文献：
  名称：

  Metwally, Mohamed Abbas; Afsah, El-Sayed; Amer, Fathy A., Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1981, vol. 36, # 9, p. 1147 - 1148

  摘要：

  DOI：
• 作为产物：
  描述：

  乙酰乙酸乙酯 、 对二甲氨基苯甲醛 在 哌啶 作用下， 以 乙醇 为溶剂， 生成 2-(4-Dimethylamino-phenyl)-4-hydroxy-4-methyl-6-oxo-cyclohexane-1,3-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  La–Sn oxide nanocatalyst: Efficient materials for the synthesis of cyclohexanones

  摘要：

  A series of La-Sn oxide catalysts were synthesized by facile low temperature hydrothermal procedure. La-Sn oxide nanoparticles were characterized by X-ray powder diffraction (XRD), field emission scanning electron microscopy (FESEM) coupled with energy dispersive spectroscopy (EDS), Fourier transform infrared (FTIR) and UV-visible spectroscopy. The FESEM and XRD analysis revealed the growth of nanoparticles with homogeneous morphology, high crystallinity and particle size of < 20 nm. The synthesized nanoparticles showed excellent catalytic activity for the synthesis of cyclohexanones. The effect of variations in La and Sn contents on the progress of reaction was estimated by yield of the products. The recovery of the catalysts after the completion of reactions was also assessed. (C) 2016 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molliq.2016.09.050

文献信息

• Sorokin; Grigor'ev; Ramazanov, Russian Journal of Organic Chemistry, 2000, vol. 36, # 6, p. 781 - 784
  作者：Sorokin、Grigor'ev、Ramazanov、Kriven'ko

  DOI：——

  日期：——
• METWALLY, M. A.;AFSAH, E. -S.;AMER, F. A., Z. NATURFORSCH., 1981, 36, N 9, 1147-1148
  作者：METWALLY, M. A.、AFSAH, E. -S.、AMER, F. A.

  DOI：——

  日期：——