2,3,4-Tris(benzyloxy)-6,8-dioxabicyclo[3.2.1]octane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,4-Tris(benzyloxy)-6,8-dioxabicyclo[3.2.1]octane
• 英文别名: 2,3,4-tris(phenylmethoxy)-6,8-dioxabicyclo[3.2.1]octane
• 化学式: C₂₇H₂₈O₅
• mdl: MFCD01820796
• 分子量: 432.5
• InChiKey: JSRSLTCFTYHIRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Compositions and methods for glucose transport inhibition
  申请人：OHIO UNIVERSITY

  公开号：US10385005B2

  公开（公告）日：2019-08-20

  Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells. Disclosed herein are novel anticancer compounds that inhibit basal glucose transport, resulting in tumor suppression and new methods for the study of glucose deprivation in animal cancer research.

  在癌症研究和治疗中，葡萄糖剥夺是一种极具吸引力的策略。癌细胞会上调葡萄糖摄取和新陈代谢，以维持加速生长和增殖速度。专门阻断这些过程有可能为了解葡萄糖转运和代谢在肿瘤发生和凋亡中的作用提供新的视角。随着实体瘤向周围血管外生长，它们会遇到营养供应有限的微环境，导致肿瘤的某些区域出现葡萄糖匮乏的环境。生活在葡萄糖匮乏环境中的癌细胞会发生变化，以防止葡萄糖匮乏诱导的细胞凋亡。了解癌细胞如何逃避凋亡诱导，还可能获得关于如何克服癌细胞对凋亡诱导的抗性的有价值的信息和知识。本文公开了新型抗癌化合物，这些化合物可抑制基础葡萄糖转运，从而抑制肿瘤，还公开了在动物癌症研究中研究葡萄糖剥夺的新方法。
• COMPOSITIONS AND METHODS FOR GLUCOSE TRANSPORT INHIBITION
  申请人：OHIO UNIVERSITY

  公开号：US20190345094A1

  公开（公告）日：2019-11-14

  Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells. Disclosed herein are novel anticancer compounds that inhibit basal glucose transport, resulting in tumor suppression and new methods for the study of glucose deprivation in animal cancer research.