5-(3-Carboxy-4-nitro-phenyl)sulfanyl-2-nitro-benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(3-Carboxy-4-nitro-phenyl)sulfanyl-2-nitro-benzoic acid
• 英文别名: 5-(3-carboxy-4-nitrophenyl)sulfanyl-2-nitrobenzoic acid
• 化学式: C14H8N2O8S
• 分子量: 364.29
• InChiKey: SVMGGVKPYCCFKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  192
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Test for the rapid evaluation of ischemic states and kits
  申请人：Bar-Or David

  公开号：US20050142613A1

  公开（公告）日：2005-06-30

  The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event. Also taught by the present invention is the detection and measurement of an ischemic event by measuring albumin N-terminal derivatives that arise following an ischemic event, including truncated albumin species lacking one to four N-terminal amino acids or albumin with an acetylated N-terminal Asp residue.

  本发明涉及检测缺血状态的快速方法和用于这种方法的试剂盒。本发明提供了一种检测和量化缺血状态的快速方法，该方法基于检测和量化缺血事件后发生的血清蛋白白蛋白变化的方法；检测和量化这种改变的方法包括评估和量化循环白蛋白的钴结合能力、分析和测量血清白蛋白结合外源钴的能力、检测和测量纯化白蛋白样本中是否存在内源铜，以及使用针对缺血事件后发生的血清白蛋白改变形式的特异性免疫测定。本发明还教导通过测量缺血事件后出现的白蛋白 N 端衍生物来检测和测量缺血事件，这些衍生物包括缺少 1 至 4 个 N 端氨基酸的截短白蛋白或具有乙酰化 N 端 Asp 残基的白蛋白。
• TESTS FOR THE RAPID EVALUATION OF ISCHEMIC STATES AND KITS
  申请人：Ischemia Technologies, Inc.

  公开号：EP1125107A1

  公开（公告）日：2001-08-22
• EP1125107A4
  申请人：——

  公开号：EP1125107A4

  公开（公告）日：2002-04-17
• ENZYME REACTION REAGENT, ENZYME REACTION REAGENT KIT AND METHOD FOR STORING LIQUID FOR ENZYMATIC REACTION
  申请人：Taiyo Nippon Sanso Corporation

  公开号：EP2397558B1

  公开（公告）日：2015-02-25
• Tests for the rapid evaluation of ischemic states and kits
  申请人：——

  公开号：US20030180820A1

  公开（公告）日：2003-09-25

  The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event. Also taught by the present invention is the detection and measurement of an ischemic event by measuring albumin N-terminal derivatives that arise following an ischemic event, including truncated albumin species lacking one to four N-terminal amino acids or albumin with an acetylated N-terminal Asp residue.