4-Pentyl-1,2-dihydropyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-Pentyl-1,2-dihydropyridine
• 化学式: C₁₀H₁₇N
• 分子量: 151.25
• InChiKey: CBSIGTDTUCUSOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] PROCESS FOR THE PREPARATION OF 4 -SUBSTITUTED -1, 4-DIHYDROPYRIDINES<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION DE 1,4-DIHYDROPYRIDINES SUBSTITUÉES EN POSITION 4
  申请人：ARCH PHARMALABS LTD

  公开号：WO2012123966A1

  公开（公告）日：2012-09-20

  4-Substituted-l,4-dihydropyridines of formula I are prepared by a cycloaddition reaction in which the cyclization is driven to completion at ambient temperature optionally in water without any catalyst. For exemplary purposes, the invention is described in particular detail with respect to the preparation of felodipine of formula II. Felodipine, a vasodilator, is prepared by a cycloaddition reaction of alkyl 3- aminocrotonate with dichlorobenzylidene under reaction conditions whereby the product crystallizes out of the reaction solution and may be directly isolated by filtration.

  通过环加成反应制备公式I的4-取代-1,4-二氢吡啶，该环化反应在室温下可在水中无需任何催化剂的情况下完全进行。为了举例说明，本发明特别详细地描述了制备公式II的非洛地平的方法。非洛地平是一种血管扩张剂，通过烷基3-氨基丙烯酸酯与二氯苯甲醛进行环加成反应制备，反应条件下产物结晶出来并可通过过滤直接分离。
• [EN] DIHYDROPYRIDINES FOR THE TREATMENT OF COGNITIVE IMPAIRMENT OR TRAUMATIC BRAIN INJURY<br/>[FR] DIHYDROPYRIDINES DESTINÉES AU TRAITEMENT D'UNE DÉFICIENCE COGNITIVE OU D'UNE LÉSION CÉRÉBRALE TRAUMATIQUE
  申请人：OHLMEYER MICHAEL

  公开号：WO2019104041A1

  公开（公告）日：2019-05-31

  A genus of dihydropyridine chemical modulators of synaptojanin is disclosed. The compounds are of the following genus: These modulators are selective inhibitors of synaptojanin 1 and may be used to treat cognitive impairment or traumatic brain injury, including promoting regeneration in cases of traumatic brain injury, or for treating neurodegenerative disorders.

  本发明揭示了一种二氢吡啶化学调节剂的属，该化合物属于以下属：这些调节剂是突触内素1的选择性抑制剂，可用于治疗认知障碍或创伤性脑损伤，包括在创伤性脑损伤的情况下促进再生，或用于治疗神经退行性疾病。
• Process for preparing 4-(4'-carboxyphenyl)pyridine
  申请人：Clariant GmbH

  公开号：US20010021778A1

  公开（公告）日：2001-09-13

  The invention relates to a process for preparing 4-(4′-carboxyphenyl)pyridine, which comprises oxidizing a 4-phenyl-N-acyldihydropyridine of the formula (II) 1 where R 1 is a bulky alkyl, alkylaryl, arylalkyl or alkoxy group and R 2 is a straight-chain or branched, substituted or unsubstituted alkyl radical having from 1 to 8 carbon atoms, by means of an oxidizing agent selected from the group consisting of permanganates, nitric acid, Cr(VI) compounds, oxygen and air to give the compound of the formula (I) 2 where M is a cation.

  本发明涉及一种制备4-(4'-羧基苯基)吡啶的方法，其包括通过使用来自高锰酸盐、硝酸、Cr(VI)化合物、氧气和空气的氧化剂，氧化式（II）的4-苯基-N-酰基二氢吡啶，其中R1是一个笨重的烷基、烷基芳基、芳基烷基或烷氧基团，而R2是一种具有1至8个碳原子的直链或支链、取代或未取代的烷基基团，以得到式（I）2的化合物，其中M是一个阳离子。
• 1,4-Dihydropyridine derivatives
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0124777A1

  公开（公告）日：1984-11-14

  Nove1 1,4-dihydropyridine derivatives have the following general Formula: and are calcium antagonists, useful for treating cardiovascular diseases.

  Nove1 1,4-二氢吡啶衍生物具有以下通式： 是钙拮抗剂，可用于治疗心血管疾病。
• 1,4-Dihydropyridine dicarboxylic acid derivatives
  申请人：ZAMBON GROUP S.p.A.

  公开号：EP0352863A2

  公开（公告）日：1990-01-31

  Compounds of formula (wherein Ar, R, R₁, R₂, R₃, R₄, R₅, m and n have the meanings given in the description), their preparation and pharmaceutical compositions containing them. The compounds of formula I are active on the cardiovascular system as antivasospastics, antiangina agents, antihyper­tensives and vasodilators.

  式化合物 (式 I 的化合物（其中 Ar、R、R₁、R₂、R₃、R₄、R₅、m 和 n 具有说明中给出的含义）、它们的制备方法和含有它们的药物组合物。 式 I 化合物作为抗血管痉挛剂、抗心绞痛剂、抗高血压剂和血管扩张剂对心血管系统具有活性。