2-chloro-N-methyl pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-chloro-N-methyl pyridine
• 英文别名: 2-chloro-1-methyl-2H-pyridine
• 化学式: C₆H₈ClN
• 分子量: 129.59
• InChiKey: MVUFMTGHIRBEKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS<br/>[FR] NOUVEAUX COMPOSÉS ET LEURS COMPOSITIONS PHARMACEUTIQUES POUR LE TRAITEMENT DE LA MUCOVISCIDOSE
  申请人：GALAPAGOS NV

  公开号：WO2014180562A1

  公开（公告）日：2014-11-13

  The present invention discloses compounds according to Formula (I), wherein R1, R2, R3, L, and the subscript m are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions, and methods of treatment using the same, for the treatment of cystic fibrosis by administering a compound of the invention.

  本发明揭示了根据式（I）的化合物，其中R1、R2、R3、L和下标m的定义如本文所述。本发明涉及这些化合物及其在囊性纤维化治疗中的应用，其生产方法，药物组合物和使用相同的治疗方法，通过给予本发明的化合物治疗囊性纤维化。
• HYALURONIC ACID DERIVATIVES OBTAINED VIA "CLICK CHEMISTRY" CROSSLINKING
  申请人：Crescenzi Vittorio

  公开号：US20100291171A1

  公开（公告）日：2010-11-18

  Crosslinked derivatives of polycarboxylated polysaccharides are described, wherein at least one of the polysaccharide chains consists of hyaluronic acid or a derivative thereof, crosslinked by means of reactions of the “click chemistry” type and their use in the field of viscosupplementation, plastic surgery, oncologic and reconstructive surgery and also as matrices for controlled release systems of biologically and/or pharmacologically active molecules and/or macromolecules.

  本文描述了多羧基多糖的交联衍生物，其中至少一个多糖链由透明质酸或其衍生物组成，通过“点击化学”反应进行交联，并在粘液补充、整形外科、肿瘤和重建手术以及作为生物和/或药理活性分子和/或大分子控制释放系统的基质中使用。
• Inner esters of gangliosides with analgesic-antiinflammatory activity
  申请人：FIDIA S.p.A.

  公开号：EP0315113A2

  公开（公告）日：1989-05-10

  A pharmaceutical composition is provided comprising inner ester ganglioside derivatives useful for its peripheral analgesic-antiinflammatory activity in treating pain caused by pathologies of the peripheral nervous system and which can advantageously be administered orally.

  一种药物组合物包含内酯神经节苷脂衍生物，该衍生物具有外周镇痛-抗炎活性，可用于治疗外周神经系统病变引起的疼痛，并且可以口服给药。
• Crosslinked carboxy polysaccharides
  申请人：FIDIA S.p.A.

  公开号：EP0341745A1

  公开（公告）日：1989-11-15

  Inter and/or intramolecular cross-linked esters of acid polysaccharides are disclosed in which a part or all of the carboxy groups are esterified with hydroxyl groups of the same molecule and/or of different molecules of the acid polysaccharide. These inner cross-linked esters of polysaccharide acids are useful in the field of biodegradable plastic materials, to manufacture sanitary and surgical articles, in the cosmetic and pharmaceutical fields, in the food industry and in many other industrial fields.

  本发明公开了酸性多糖的分子间和/或分子内交联酯，其中部分或全部羧基与酸性多糖同一分子和/或不同分子的羟基酯化。这些内交联多糖酸酯可用于生物可降解塑料材料领域、卫生和外科用品制造领域、化妆品和医药领域、食品工业和许多其他工业领域。
• ORGANIC METAL COMPOUND, ORGANIC LIGHT EMITTING DIODE AND ORGANIC LIGHT EMITTING DEVICE HAVING THE COMPOUND
  申请人：LG Display Co., Ltd.

  公开号：EP4015521A1

  公开（公告）日：2022-06-22

  The present disclosure relates to an organic metal compound having the following structure of Formula 1, an organic light emitting diode (OLED) (D, D1, D2, D3) and an organic light emitting device that includes the organic metal compound. The OLED (D, D1, D2, D3) and the organic light emitting device including the organic metal compound can improve their luminous efficiency, luminous color purity and lifespan.         [Formula 1]     Ir(LA)m(LB)n

  本公开涉及一种具有如下式 1 结构的有机金属化合物、一种有机发光二极管（OLED）（D、D1、D2、D3）和一种包括该有机金属化合物的有机发光器件。该有机发光二极管（D、D1、D2、D3）和包括该有机金属化合物的有机发光器件可提高其发光效率、光色纯度和寿命。 [式 1] Ir(LA)m(LB)n