1-(5-Pyridin-1-ium-1-ylpentyl)pyridin-1-ium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(5-Pyridin-1-ium-1-ylpentyl)pyridin-1-ium
• 化学式: C15H20N2+2
• 分子量: 228.33
• InChiKey: NCRGGUSSYXSHOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  7.8
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• Bis-pyridino containing compounds for the use in the treatment of CNS pathologies
  申请人：Crooks A. Peter

  公开号：US20050261334A1

  公开（公告）日：2005-11-24

  N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.

  尼古丁的N-n-烷基化将尼古丁从激动剂转化为拮抗剂，特别是对于介导尼古丁诱导的多巴胺释放的神经尼古丁乙酰胆碱受体亚型。构象限制类似物在该位点表现出高亲和力和选择性，并能够进入大脑，因为它们能够作为血脑屏障胆碱转运体的底物。
• BIS-PYRINDINO CONTAINING COMPOUNDS FOR THE USE IN THE TREATMENT OF CNS PATHOLOGIES
  申请人：CROOKS Peter A.

  公开号：US20100152237A1

  公开（公告）日：2010-06-17

  N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.

  尼古丁的N-烷基化将尼古丁从激动剂转变为拮抗剂，特别针对介导尼古丁引起多巴胺释放的神经尼古丁乙酰胆碱受体亚型。构象限制性类似物在该位点表现出高亲和力和选择性，并能够进入大脑，因为它们能够作为血脑屏障胆碱转运体的底物。
• DICATIONIC LIQUID SALTS AND METHODS OF USE THEREOF
  申请人：Daniel Armstrong W.

  公开号：US20110017908A1

  公开（公告）日：2011-01-27

  Dicationic liquid salts and methods of using such dicationic liquid salts in techniques such as ESI-MS are provided.
• HIGH STABILITY DIIONIC LIQUID SALTS
  申请人：Armstrong Daniel W.

  公开号：US20120211696A1

  公开（公告）日：2012-08-23

  The present invention relates to diionic liquid salts of dicationic or dianionic molecules, as well as solvents comprising such diionic liquids and the use of such diionic liquids as the stationary phase in a gas chromatographic column.
• METHODS FOR QUANTITATING WATER USING IONIC LIQUID SALTS
  申请人：SIGMA-ALDRICH CO. LLC

  公开号：US20130074580A1

  公开（公告）日：2013-03-28

  This disclosure provides methods and devices for quantitating, separating and/or detecting water in a liquid, gas or solid sample comprising one or more chemicals, the method comprising: providing the liquid, gas or solid sample comprising water and the one or more chemicals; and exposing said liquid, gas or solid sample to at least one solid support including at least one dicationic and/or tricationic species of Formula I or II adsorbed, absorbed or immobilized on the solid support.