O-(4,4-diphenylbutyl)hydroxylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: O-(4,4-diphenylbutyl)hydroxylamine
• 化学式: C₁₆H₁₉NO
• 分子量: 241.33
• InChiKey: FDORCDNXELDTEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• ANTIMETABOLITE AGENT COMBINATIONS IN THE TREATMENT OF CANCER
  申请人：LIU LILI

  公开号：US20100267657A1

  公开（公告）日：2010-10-21

  A method treating cancer in a subject comprises administering to the subject a therapeutically effective amount of an antimetabolite agent that induces formation of AP sites in cancer cells of the subjects and an amount AP endonuclease inhibitor effective to potentiate the cytotoxicity of the antimetabolite agent to the cancer cells.
• ALKYLATING AGENT COMBINATIONS IN THE TREATMENT OF CANCER
  申请人：Gerson Stanton L.

  公开号：US20120065145A1

  公开（公告）日：2012-03-15

  This application provides compositions and methods useful in the treatment of certain cancers. In part, this application is based on the recognition that certain molecules that target abasic lesions or AP sites in DNA improve, augment, or potentiate the chemotherapeutic efficacy of certain anticancer agents.
• METHODS OF DIAGNOSING AND TREATING CANCER
  申请人：Case Western Reserve University

  公开号：US20140066464A1

  公开（公告）日：2014-03-06

  A method of determining the susceptibility of a cancer in a subject to treatment with an antimetabolite includes obtaining a sample of cancer cells from the subject, measuring the level of UDG expression in the cancer cells, and comparing the measured levels of UDG expression in the cancer cells to a control level.
• US8324282B2
  申请人：——

  公开号：US8324282B2

  公开（公告）日：2012-12-04
• US8716346B2
  申请人：——

  公开号：US8716346B2

  公开（公告）日：2014-05-06