triphenyl(prop-2-enyl)-λ5-phosphane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: triphenyl(prop-2-enyl)-λ5-phosphane
• 化学式: C₂₁H₂₁P
• 分子量: 304.4
• InChiKey: UXGFQAGHVSELFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• [EN] HETEROCYCLIC COMPOUNDS AND THEIR USE IN PREVENTING OR TREATING BACTERIAL INFECTIONS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEUR UTILISATION DANS LA PRÉVENTION OU LE TRAITEMENT D'INFECTIONS BACTÉRIENNES
  申请人：MUTABILIS

  公开号：WO2018060481A1

  公开（公告）日：2018-04-05

  The invention relates to a compound of formula (I) and a racemate, an enantiomer, a diastereoisomer, a geometric isomer or a pharmaceutically acceptable salt thereof, and its use as antibacterial agent.

  这项发明涉及一种式(I)的化合物及其外消旋体、对映体、二对映异构体、几何异构体或药学上可接受的盐，并且其作为抗菌剂的用途。
• [EN] VITAMIN D ANALOGUES, COMPOSITIONS COMPRISING SAID ANALOGUES AND THEIR USE<br/>[FR] ANALOGUES DE LA VITAMINE D, COMPOSITIONS COMPRENANT LESDITS ANALOGUES ET LEUR UTILISATION
  申请人：LEO PHARMA AS

  公开号：WO2004037781A1

  公开（公告）日：2004-05-06

  Compounds according to formula I: in which formula R1 and R2, which may be the same or different, represent halogen, (C1-C6) hydrocarbyl, optionally substituted with one or two hydroxyl group on one or more fluorine atoms, or, together with the carbon atom to which they are both attached, R1 and R2 form a (C3-C6)carbocyclic ring, or one of R1 and R2 taken together with R3 forms a direct bond, such that a triple bond is constituted, or R1 and R2 represent both hydrogen; R3 when not forming a direct bond with one of R1 and R2 represents hydrogen or (C1-C3)hydrocarbyl; X represents (E)-ethylene, (Z)-ethylene, ethynylene, or a bond; Y and Z independently represent hydrogen or methyl; the bond between C#16 and C#17 is depicted with a dotted line to illustrate that said bond may be either a single bond, in which case the projection of the ring substituents is beta, or a double bond; A represents hydroxyl, fluorine or hydrogen; B represents CH2 or H2; the configuration is the 3-position corresponds to the same configuration as in natural vitamine D3 (normal), or the configuration in the configuration in the 3-position is opposite to that of natural vitamin D3(epi); with the proviso that when X represents (E)-ethylene or (Z)-ethylene, one of R1 and R2 taken together with R3 may not form a direct bond, such that a triple bond is constituted; with the further proviso that when X represents a bond R1 ands R2 are nor hydrogen; with the further proviso that the compound of formula I is not 3(S)-hyroxy-9, 10-secocholesta-5(Z),7(E),10(19),22(E),24-penta-ene; and prodrugs and stereo isomeric forms thereof are provided together with their use in therapy, and their use in the manufacture of medicaments.

  根据公式I：其中公式中的R1和R2，可以相同也可以不同，代表卤素，(C1-C6)烃基，可选地在一个或多个氟原子上用一个或两个羟基取代，或者，与它们都连接的碳原子一起，R1和R2形成一个(C3-C6)碳环，或者R1和R2中的一个与R3一起形成直接键，从而构成三键，或者R1和R2都代表氢；当R3不与R1和R2中的一个形成直接键时，代表氢或(C1-C3)烃基；X代表(E)-乙烯，(Z)-乙烯，乙炔基，或者一个键；Y和Z独立地代表氢或甲基；C#16和C#17之间的键用虚线表示，以说明该键可以是单键，此时环取代基的投影为β，或者是双键；A代表羟基，氟或氢；B代表CH2或H2；3位的构型与天然维生素D3 (正常)中的构型相对应，或者3位的构型与天然维生素D3 (epi)中的构型相反；但是当X代表(E)-乙烯或(Z)-乙烯时，R1和R2中的一个与R3一起不能形成直接键，从而构成三键；进一步的条件是，当X代表一个键时，R1和R2不是氢；进一步的条件是，公式I的化合物不是3(S)-羟基-9,10-去甲胆骨化甾-5(Z),7(E),10(19),22(E),24-五烯；还提供了它们的前药和立体异构体形式，以及它们在治疗中的用途，以及它们在药物制造中的用途。
• PROCESS FOR THE PRODUCTION OF TRIARYL ORGANOBORATES
  申请人：Covestro Deutschland AG

  公开号：US20190276479A1

  公开（公告）日：2019-09-12

  The invention relates to a process for preparing triaryl organoborates proceeding from alkyl or cycloalkyl boronates in the presence of an n-valent cation 1/n K n+ and to the use of these substances as co-initiator in photopolymer formulations.

  这项发明涉及一种制备三芳基有机硼酸盐的过程，该过程从烷基或环烷基硼酸盐在n价阳离子1/n Kn+存在下进行，并将这些物质用作光聚合物配方中的协同引发剂。
• Mitochondria-Targeted Inhibitors of Cytochrome C Peroxidase for Protection from Apoptosis
  申请人：Atkinson Jeffrey

  公开号：US20130203829A1

  公开（公告）日：2013-08-08

  The present application is directed to novel imidazole-substituted fatty acids that have been functionalized with an alkyl triphenylphosphonium group, compositions comprising these compounds and their use as inhibitors of cytochrome c peroxidase, in particular for the treatment and prevention of apoptosis.

  本申请涉及一种新型咪唑基取代脂肪酸，其已被烷基三苯基膦基团官能化，包括这些化合物的组合物以及它们作为细胞色素c过氧化物酶抑制剂的用途，特别用于治疗和预防凋亡。
• [EN] N-1 BRANCHED ALKYL SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS, COMPOSITIONS, AND METHODS<br/>[FR] COMPOSÉS IMIDAZO[4,5-C]QUINOLÉINE SUBSTITUÉS PAR ALKYLE N-1 RAMIFIÉ, COMPOSITIONS ET PROCÉDÉS
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2020245706A1

  公开（公告）日：2020-12-10

  Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing (or inhibiting) cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.

  本发明公开了在N-1位置通过支链基团连接的Imidazo[4,5-c]喹啉化合物，化合物的单对映体，含有这些化合物的药物组合物，以及制备这些化合物的方法。还公开了将这些化合物用作免疫应答调节剂的方法，用于诱导（或抑制）人类和动物体内的细胞因子生物合成，并用于治疗包括传染性和肿瘤性疾病在内的疾病的方法。