2-[4-Methyl-3-[(2-nitrophenyl)methyl]-1,3-thiazol-3-ium-5-yl]ethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-Methyl-3-[(2-nitrophenyl)methyl]-1,3-thiazol-3-ium-5-yl]ethanol
• 化学式: C13H15N2O3S+
• 分子量: 279.34
• InChiKey: WAILYTOKQIBJLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  98.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Method and composition for rejuvenating hair, nails, tissues, cells and organs by ex-vivo or immersive treatment
  申请人：——

  公开号：US20020182165A1

  公开（公告）日：2002-12-05

  A method and composition for the treatment of hair, nail, ex-vivo organ, ex-vivo cell or ex-vivo tissue to improve the biomechanical and diffusional characteristics comprising an effective amount of a compound selected from the group consisting of compounds of the formula 1

  一种用于改善生物力学和扩散特性的头发、指甲、离体器官、离体细胞或离体组织的治疗方法和组合物，包括有效量的来自化合物公式1所述化合物组合的化合物。
• Thiazoliums as transketolase inhibitors
  申请人：Boyd Steven A.

  公开号：US20090209554A1

  公开（公告）日：2009-08-20

  The present invention provides N-3′-pyridyl-methyl or N-2′-pyrazinylmethyl thiazolium derivatives of formula (I) which are useful as transketolase inhibitors wherein R 1 , R 2 , R 3 , Y, R 5 -R 9 , R a -R d , n and X − are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.

  本发明提供了式（I）的N-3'-吡啶甲基或N-2'-吡嗪甲基噻唑盐衍生物，其作为转酮糖酶抑制剂是有用的，其中R1、R2、R3、Y、R5-R9、Ra-Rd、n和X-如本文所定义。本发明还提供了包含式（I）的化合物的制药组合物。本发明提供了通过给予式（I）的化合物或其制药组合物来抑制转酮糖酶活性、降低细胞核糖-5-磷酸水平、抑制核酸合成、抑制细胞增殖和肿瘤细胞在体内和体外生长、刺激肿瘤细胞凋亡和治疗癌症的方法。
• USE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS
  申请人：ALTEON Inc.

  公开号：EP0808163B1

  公开（公告）日：2003-07-23
• US6440749B1
  申请人：——

  公开号：US6440749B1

  公开（公告）日：2002-08-27