3-(triphenyl-λ5-phosphanyl)propanenitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(triphenyl-λ5-phosphanyl)propanenitrile
• 化学式: C₂₁H₂₀NP
• 分子量: 317.4
• InChiKey: XKCPOSDKTUSVLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] TREATMENT AND PREVENTION OF HBV DISEASES BY CYCLOSPORINE ANALOGUE MOLECULES MODIFIED AT AMINO ACIDES 1 AND 3<br/>[FR] TRAITEMENT ET PRÉVENTION DE MALADIES DU VHB PAR DES MOLÉCULES ANALOGUES DE CYCLOSPORINE MODIFIÉES AU NIVEAU DES ACIDES AMINÉS 1 ET 3
  申请人：CONTRAVIR PHARMACEUTICALS INC

  公开号：WO2018106928A1

  公开（公告）日：2018-06-14

  The present application relates to a method of treating and/or preventing a hepatitis B virus (HBV) disease through inhibiting the interaction of CypA with HBV X protein (HBx) and/or Hepatitis B surface antigen (HBsAg), comprising administering to a subject in need thereof a compound of Formula L.

  本申请涉及一种通过抑制CypA与乙型肝炎病毒（HBV）X蛋白（HBx）和/或乙型肝炎表面抗原（HBsAg）的相互作用来治疗和/或预防乙型肝炎病毒（HBV）疾病的方法，包括向需要的受试者施用一种L式化合物。
• NONIMMUNOSUPPRESSIVE CYCLOSPORINE ANALOGUE MOLECULES
  申请人：Hegmans Alexander

  公开号：US20130190223A1

  公开（公告）日：2013-07-25

  The compounds of the present invention are non-immunosupressive cyclosporine analogue molecules that are able to bind cyclophilin. Said compounds include a modified side chain of amino acid I of cyclosporin A, consisting of an oxyalkyl having substituents R′, R1 and R2, where R′ is H or Acetyl; R1 is a saturated or unsaturated straight chain or branched aliphatic carbon chain; and R2 may be a hydrogen; a unsubstituted, N substituted or NN disubstituted amide; a N substituted or unsubstituted acyl protected amine; a carboxylic acid; a N substituted or unsubstituted amine; a nitrile; a ester; a ketone; a hydroxy, dihydroxy, trihydroxy or polyhydroxy alkyl; or a substituted or unsubstituted aryl.
• CYCLOSPORINE ANALOGUE MOLECULES MODIFIED AT AMINO ACID 1 AND 3
  申请人：Hegmans Alexander

  公开号：US20140142033A1

  公开（公告）日：2014-05-22

  Analogues of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.
• Cyclosporine Analogue Molecules Modified At Amino Acid 1 and 3
  申请人：Ciclofilin Pharmaceuticals Corp.

  公开号：US20160207961A1

  公开（公告）日：2016-07-21

  Analogues of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.
• US9200038B2
  申请人：——

  公开号：US9200038B2

  公开（公告）日：2015-12-01