METHYL/DIFLUOROPHENYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, METHYL-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, AND METHYL-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS
申请人:Confluence Life Sciences INC.
公开号:US20130274272A1
公开(公告)日:2013-10-17
The present disclosure provides methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I):
wherein R
1
, R
2
, R
3
and X are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.
本公开提供了甲基/二氟苯基-甲氧基取代的吡啶酮-吡啶基化合物,甲基-吡啶基-甲氧基取代的吡啶酮-吡啶基化合物,以及甲基-嘧啶基-甲氧基取代的吡啶酮-吡啶基化合物,其结构式为(I),可用于治疗p38激酶介导的疾病,如淋巴瘤和自身免疫性疾病,其中R1、R2、R3和X如详细说明中所定义;包括至少一种该化合物的药物组合物;以及使用该化合物治疗p38激酶介导的疾病的方法。