tris(4-chlorophenyl)-methyl-λ5-phosphane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tris(4-chlorophenyl)-methyl-λ5-phosphane
• 化学式: C₁₉H₁₆Cl₃P
• 分子量: 381.7
• InChiKey: YLMQCAWXUBFGMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• USE OF SILVER(I) COMPLEXES AS ANTICANCER AGENTS
  申请人：University of Johannesburg

  公开号：US20170239208A1

  公开（公告）日：2017-08-24

  The present invention relates to the use of silver(I) monophosphine complexes as Active Pharmaceutical Ingredients (API's), including anticancer agents, for the treatment, diagnosis and/or prevention of cancer. The present invention also relates to pharmaceutical compositions containing such complexes and further extends to a method of treating or diagnosing a subject/patient suffering from cancer.

  本发明涉及使用银(I)单膦配合物作为活性药物成分(API)，包括抗癌药物，用于治疗、诊断和/或预防癌症。本发明还涉及含有这种配合物的制药组合物，并进一步扩展到治疗或诊断患有癌症的受试者/患者的方法。
• Phosphonium salts of N-phosphonomethylglycine, preparation and compositions thereof and the use thereof as herbicides and plant growth regulants
  申请人：STAUFFER CHEMICAL COMPANY

  公开号：EP0073574A1

  公开（公告）日：1983-03-09

  A compound characterised in that it consists essentially of a phosphonium cation and a glycylmethyl phosphonate anion is disclosed. More particularly, such compounds correspond to the following general formula (I): wherein R1, R2, R3 and R4 independently represent C1-C10 alkyl, optionally substituted benzyl or optionally substituted phenyl, the substituents being selected from halogen C1-C4 alkoxy and C1-C4 alkyl, provided that at least one or R1, R2. R3 and R4 represents optionally substituted benzyl or substituted phenyl; or to the following general formula (II): wherein R1, R2, R3 and R4 independently represent C1-C10 alkyl or phenyl. Sucn compounds may be used as herbicides and plant growth regulants.

  本发明公开了一种化合物，其特征在于该化合物主要由鏻阳离子和甘氨酰甲基膦酸阴离子组成。 更具体地说，这种化合物符合以下通式 (I)： 其中 R1、R2、R3 和 R4 独立地代表 C1-C10 烷基、任选取代的苄基或任选取代的苯基，取代基选自卤素 C1-C4 烷氧基和 C1-C4 烷基，条件是 R1、R2、R3 和 R4 中至少有一个代表任选取代的苄基或苯基。R3和R4中至少有一个代表任选取代的苄基或取代的苯基； 或以下通式(II)： 其中 R1、R2、R3 和 R4 独立地代表 C1-C10 烷基或苯基。 琥珀酸化合物可用作除草剂和植物生长调节剂。
• Phosphonium-ion tethered tetracycline drugs for treatment of cancer
  申请人：Oxford University Innovation Limited

  公开号：US11161862B2

  公开（公告）日：2021-11-02

  This invention relates to compounds that are useful as cancer therapies. The compounds comprise derivatives of tetracycline antibiotics, e.g. doxycycline, having a phosphonium cation tethered to the tetracycline tetracycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

  本发明涉及可用作癌症疗法的化合物。这些化合物包括四环素类抗生素（如强力霉素）的衍生物，其鏻阳离子与四环素四环相连。本发明还涉及使用所述化合物的方法和包含所述化合物的药物制剂。
• PHOSPHONIUM-ION TETHERED TETRACYCLINE DRUGS FOR TREATMENT OF CANCER
  申请人：Rising Tide Foundation

  公开号：US20200123182A1

  公开（公告）日：2020-04-23

  This invention relates to compounds that are useful as cancer therapies. The compounds comprise derivatives of tetracycline antibiotics, e.g. doxycycline, having a phosphonium cation tethered to the tetracycline tetracycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.
• US4525202A
  申请人：——

  公开号：US4525202A

  公开（公告）日：1985-06-25