methyl 2-[(triphenyl-λ5-phosphanyl)methyl]benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2-[(triphenyl-λ5-phosphanyl)methyl]benzoate
• 化学式: C₂₇H₂₅O₂P
• 分子量: 412.5
• InChiKey: DBGSTPGYLZGWHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase
  申请人：Quagliato Dominick Anthony

  公开号：US20070203116A1

  公开（公告）日：2007-08-30

  The present invention provides a 10,11-dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol]-5′(1′H)-one compound of formula I Also provided are methods and compositions for the inhibition of β-secretase (BACE) and the treatment of β-amyloid deposits and neurofibrillary tangles.

  本发明提供了一种式I的10,11-二氢螺[二苯并[a,d][7]环戊二烯-5,4′-咪唑]-5′(1′H)-酮化合物。还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法和组合物。
• [EN] PHENYLCARBOXYLIC ACID DERIVATIVES AND USE THEREOF FOR THE TREATMENT OF DIABETES<br/>[FR] DERIVES D'ACIDE PHENYLCARBOXYLIQUE, ET LEUR UTILISATION POUR TRAITER LE DIABETE
  申请人：MERCK PATENT GMBH

  公开号：WO2006000288A1

  公开（公告）日：2006-01-05

  The invention relates to compounds of general formula (1): in which R1, R2, R3, R4, R5, A, B, D and E are as defined in Claim 1, and also to the preparation process therefor and the therapeutic use thereof. These compounds can be used in the treatment of pathologies associated with hyperglycaemia.

  该发明涉及一般式（1）的化合物：其中R1、R2、R3、R4、R5、A、B、D和E如权利要求1所定义，并且还涉及其制备过程和治疗用途。这些化合物可用于治疗与高血糖相关的病理。
• Phenylcarboxylic Acid Derivatives and Use Thereof for the Treatment of Diabetes
  申请人：Moinet Gerard

  公开号：US20080045483A1

  公开（公告）日：2008-02-21

  The invention relates to compounds of general formula (1): in which R1, R2, R3, R4, R5, A, B, D and E are as defined in Claim 1 , and also to the preparation process therefor and the therapeutic use thereof. These compounds can be used in the treatment of pathologies associated with hyperglycaemia.

  本发明涉及一般式（1）的化合物：其中R1、R2、R3、R4、R5、A、B、D和E如权利要求书所定义，并且涉及其制备过程和治疗用途。这些化合物可用于治疗与高血糖相关的病理状况。
• Dibenzocycloheptane compounds and pharmaceuticals containing these compounds
  申请人：Laufer Stefan

  公开号：US20090105327A1

  公开（公告）日：2009-04-23

  The present invention relates to compounds of the formula I in which R1, R2, R3, R4, X and Y have the meanings indicated in the description. These compounds have immunomodulating effects, as well as an inhibiting or regulating effect on the release of IL-1β and/or TNF-α. They can therefore be used for the treatment of diseases associated with a disturbance of the immune system.

  本发明涉及式I的化合物，其中R1、R2、R3、R4、X和Y具有描述中所示的含义。这些化合物具有免疫调节作用，以及对IL-1β和/或TNF-α的释放具有抑制或调节作用。因此，它们可用于治疗与免疫系统紊乱相关的疾病。
• PHENYLCARBOXYLIC ACID DERIVATIVES AND USE THEREOF FOR THE TREATMENT OF DIABETES
  申请人：Merck Patent GmbH

  公开号：EP1761486A1

  公开（公告）日：2007-03-14