Benzyl(triethyl)azanium;sulfuric acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzyl(triethyl)azanium;sulfuric acid
• 化学式: C13H24NO4S+
• 分子量: 290.4
• InChiKey: MEPLDDAONLVHEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.41
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] PROCESS FOR THE PREPARATION OF 11-(4-[2-(2-HYDROXYETHOXY)ETHYL]-I-PIPERAZINYL)DIB ENZO[b,f][l,4]THIAZEPINE<br/>[FR] PROCEDE DE PREPARATION DE 11-(4-[2-(2-HYDROXYETHOXY)ETHYL]-I-PIPERAZINYL)DIB ENZO[B,F][L,4]THIAZEPINE
  申请人：SK CORP

  公开号：WO2006001619A1

  公开（公告）日：2006-01-05

  Disclosed is a process for the preparation of l l-(4-[2-(2-hydroxyethoxy)ethyl]-l- piperazinyl)-dibenzo[b,f][l,4]thiazepine. In the process, low-priced 2,2'-dithiosalicylic acid as starting material is subjected to bond formation reaction with l-chloro-2- 5 nitrobenzene in a basic aqueous solution, a nitro group reduction reaction is conducted, cyclization and chlorination reactions are simultaneously carried out in the presence of a equivalent amount of halogenating agent, a reaction with piperazine is continuously conducted without separation, and a reaction with 2-haloethoxyethanol is conducted, thereby it is possible to economically producing Quetiapine, that is, l l-(4-[2-(2- 10 hydroxyethoxy)ethyl]-l-piperazinyl)-dibenzo[b,fj[l,4]thiazepine, in an environmentally friendly manner. Particularly, the process is advantageous in that economic efficiency is assured because of use of the low-priced starting material, use of an organic solvent is minimized because a reaction is conducted in an aqueous solution, and it is possible to achieve the environmentally friendly and economical process having high commercial 15 usefulness because the number of reaction steps of the process is reduced and because generation of acidic waste is minimized.

  公开了一种制备 l l-(4-[2-(2-羟基乙氧基)乙基]-l-哌嗪基)-二苯并[b,f][1,4]噻二嗪的过程。在该过程中，以低价的2,2'-二硫基水杨酸作为起始物质，经过与1-氯-2-5-硝基苯基的键合反应，在碱性水溶液中进行硝基还原反应，同时在存在等量卤化剂的情况下进行环化和氯化反应，与哌嗪的反应连续进行而不分离，并进行与2-卤乙氧基乙醇的反应，从而可以在环保的方式下经济地生产奎提亚平，即l l-(4-[2-(2-羟基乙氧基)乙基]-l-哌嗪基)-二苯并[b,f][1,4]噻二嗪。特别是，该过程具有经济效益，因为使用了低价的起始物质，由于反应在水溶液中进行，有机溶剂的使用被最小化，并且由于减少了过程的反应步骤和酸性废物的生成，可以实现具有高商业实用性的环保和经济过程。
• Process for the Preparation of 11-(4-[2-(2-Hydroxyethoxy)Ethyl]-I-Piperazinyl)Dibenzo[b,f][I,4]Thiazepine
  申请人：Kwak Sung Byong

  公开号：US20070225494A1

  公开（公告）日：2007-09-27

  Disclosed is a process for the preparation of 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine. In the process, low-priced 2,2′-dithiosalicylic acid as starting material is subjected to bond formation reaction with 1-chloro-2-nitrobenzene in a basic aqueous solution, a nitro group reduction reaction is conducted, cyclization and chlorination reactions are simultaneously carried out in the presence of a equivalent amount of halogenating agent, a reaction with piperazine is continuously conducted without separation, and a reaction with 2-haloethoxyethanol is conducted, thereby it is possible to economically producing Quetiapine, that is, 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine, in an environmentally friendly manner. Particularly, the process is advantageous in that economic efficiency is assured because of use of the low-priced starting material, use of an organic solvent is minimized because a reaction is conducted in an aqueous solution, and it is possible to achieve the environmentally friendly and economical process having high commercial usefulness because the number of reaction steps of the process is reduced and because generation of acidic waste is minimized.

  本发明涉及一种制备11-(4-[2-(2-羟乙氧基)乙基]-1-哌嗪基)-二苯并[b,f][1,4]噻吩的方法。在该方法中，以低价的2,2'-二硫基水杨酸为起始物质，在碱性水溶液中进行键合反应，与1-氯-2-硝基苯发生还原反应，同时在卤化剂的等量存在下进行环化和氯化反应，连续进行哌嗪反应而无需分离，最后进行2-卤乙氧基乙醇反应，从而可以在环保的条件下经济地生产喹硫平，即11-(4-[2-(2-羟乙氧基)乙基]-1-哌嗪基)-二苯并[b,f][1,4]噻吩。特别地，该方法具有以下优点：利用低价起始物质保证经济效益，由于反应在水溶液中进行，最小化了有机溶剂的使用，因此可以实现环保和经济的高商业价值的过程，同时由于减少了反应步骤的数量并最小化了酸性废物的产生，因此也具有高商业实用性。
• A process for producing steroid derivatives
  申请人：NIPPON KAYAKU KABUSHIKI KAISHA

  公开号：EP0261656A1

  公开（公告）日：1988-03-30

  A process for producing a steroid compound which is useful as an intermediate for synthesizing plant growth regulators, brassinosteroids, and is represented by the general formula (4): wherein R₁ is in which R₂ is a methyl or ethyl, and * indicates the binding site of R₁ to a steroid nucleus, or general formula (5): where in R₁ is as defined above. According to the process disclosed herein, an intermediate for a brassinolide, epibrassinolide, homobrassinolide or derivatives thereof can be produced highly advantageously in the industries.

  一种类固醇化合物的生产工艺，该化合物可用作合成植物生长调节剂--铜生长激素的中间体，其通式为(4)： 其中 R₁ 是 其中 R₂ 是甲基或乙基，* 表示 R₁ 与类固醇核的结合位点，或 通式 (5)： 其中 R₁ 如上定义。 根据本文所公开的工艺，可以在工业中生产出非常有利的黄铜内酯、表黄铜内酯、同黄铜内酯或其衍生物的中间体。
• PROCESS FOR THE PREPARATION OF 11-(4-[2-(2-HYDROXYETHOXY)ETHYL]-I-PIPERAZINYL)DIBENZO[B,F][1,4]THIAZEPINE
  申请人：SK Corporation

  公开号：EP1781646A1

  公开（公告）日：2007-05-09
• EP1781646A4
  申请人：——

  公开号：EP1781646A4

  公开（公告）日：2009-03-04