thermopsine

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 羽扇豆生物碱
• 英文名称: thermopsine
• 英文别名: (1S,9R,10S)-7,15-Diazatetracyclo[7.7.1.02,7.010,15]heptadeca-2,4-dien-6-one
• 化学式: C₁₅H₂₀N₂O
• 分子量: 244.337
• InChiKey: FQEQMASDZFXSJI-XQQFMLRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  thermopsine 在 硫酸 、 双氧水 、 potassium bromide 作用下， 以73%的产率得到3,5-dibromothermopsine
  参考文献：
  名称：

  Synthesis of Several 3,5- and 3-Substituted Thermopsine Derivatives

  摘要：

  DOI：

  10.1007/s10600-015-1419-0

文献信息

• EP2724156B1
  申请人：——

  公开号：EP2724156B1

  公开（公告）日：2017-08-16
• METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASE
  申请人：THE JACKSON LABORATORY

  公开号：US20130184342A1

  公开（公告）日：2013-07-18

  The technology described herein relates to methods of inducing cell death. The technology described herein further relates to treating conditions including cancers and autoimmune diseases comprising administering inhibitors of double strand break repair. Also described herein are inhibitors of double strand break repair and methods of screening for such inhibitors.
• [EN] METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASE<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LE TRAITEMENT DU CANCER ET D'UNE MALADIE AUTO-IMMUNE
  申请人：JACKSON LAB

  公开号：WO2013003112A1

  公开（公告）日：2013-01-03

  The technology described herein relates to methods of inducing cell death. The technology described herein further relates to treating conditions including cancers and autoimmune diseases comprising administering inhibitors of double strand break repair. Also described herein are inhibitors of double strand break repair and methods of screening for such inhibitors.