N-methyl-2,3,7,8-tetramethoxy-5,6-dihydrobenzophenanthridine-6-ethanoic acid

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 苯并菲啶生物碱
• 英文名称: N-methyl-2,3,7,8-tetramethoxy-5,6-dihydrobenzophenanthridine-6-ethanoic acid
• 英文别名: N-Methyl-2,3,7,8-tetramethoxy-5,6-dihydrobenzophenathridine-6-ethanoic acid；2-[(6S)-2,3,7,8-tetramethoxy-5-methyl-6H-benzo[c]phenanthridin-6-yl]acetic acid
• 化学式: C₂₄H₂₅NO₆
• 分子量: 423.466
• InChiKey: ITTVQFYNAAJGHT-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  77.5
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-methyl-2,3,7,8-tetramethoxy-5,6-dihydrobenzophenanthridine-6-ethanoic acid 在 lithium aluminium tetrahydride 作用下， 以 甲醇 、 乙醚 、 氯仿 为溶剂， 生成 2-((S)-2,3,7,8-Tetramethoxy-5-methyl-5,6-dihydro-benzo[c]phenanthridin-6-yl)-ethanol
  参考文献：
  名称：

  Benzophenanthridine Alkaloids from Corydalis flabellata

  摘要：

  Four new alkaloids, characterized as 6-(2-hydroxyethyl)-5,6-dihydrosanguinarine (1), 6-acetonyl-5,6-dihydrosanguinarine (2), N-methyl-2,3,7,8-tetramethoxy-5,6-dihydrobenzophenanthridine-6-ethanoic acid (3), N-methyl-2,3,7,8-tetramethoxy-6-oxo-5,6-dihydrobenzophenanthridine (4), together with oxosanguinarine (5), spallidamine (6), 6-acetonyl-5,6-dihydrochelerythrine (7), 6-oxochelerythrine (8) and sanguidimerine (9) were isolated from the roots of Corydalis flabellata.

  DOI：

  10.1055/s-2002-23131

文献信息

• Benzophenanthridine Alkaloids from Corydalis flabellata
  作者：Summon Koul、T. K. Razdan、C. S Andotra、A. K. Kalla、S. Koul、S. C. Taneja

  DOI：10.1055/s-2002-23131

  日期：2002.3

  Four new alkaloids, characterized as 6-(2-hydroxyethyl)-5,6-dihydrosanguinarine (1), 6-acetonyl-5,6-dihydrosanguinarine (2), N-methyl-2,3,7,8-tetramethoxy-5,6-dihydrobenzophenanthridine-6-ethanoic acid (3), N-methyl-2,3,7,8-tetramethoxy-6-oxo-5,6-dihydrobenzophenanthridine (4), together with oxosanguinarine (5), spallidamine (6), 6-acetonyl-5,6-dihydrochelerythrine (7), 6-oxochelerythrine (8) and sanguidimerine (9) were isolated from the roots of Corydalis flabellata.