3,5-Dicarbamoylbenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-Dicarbamoylbenzoic acid
• 化学式: C₉H₈N₂O₄
• 分子量: 208.17
• InChiKey: PWHLZHNUIIIZPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED HYDROXYETHYLAMINES<br/>[FR] HYDROXYETHYLAMINES SUBSTITUES
  申请人：ELAN PHARM INC

  公开号：WO2003050073A1

  公开（公告）日：2003-06-19

  Disclosed are compounds of the formula (I) and the pharmaceutically acceptable salts thereof wherein the variables G, L, A, W, E, R2, R3, R4, R5, RN, and RC are defined herein. These compounds interact with and inhibit the activity of the enzyme beta- secretase. These compounds are therefore useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions and methods of treatment of these diseases are also disclosed.