[1-(2-(18F)fluoranylethyl)piperidin-3-yl] 2-hydroxy-2,2-diphenylacetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [1-(2-(18F)fluoranylethyl)piperidin-3-yl] 2-hydroxy-2,2-diphenylacetate
• 化学式: C21H24FNO3
• 分子量: 356.4
• InChiKey: KDHBCIPPYVMWKR-KVTPGWOSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Synthesis of 18F-labeled Tracers in Hydrous Organic Solvents
  申请人：Gangadharmath Umesh

  公开号：US20130005956A1

  公开（公告）日：2013-01-03

  A method for synthesizing an 18 F-labeled probe. The method includes a step of eluting an amount of 18 F with a first solvent which includes a predetermined amount of water and at least one organic solvent. In this step, the 18 F elutes as an 18 F solution. The method also includes a step of using the 18 F solution to perform 18 F-labeling in the presence of at least one labeling reagent and at least one phase transfer catalyst so as to generate the 18 F-labeled probe. In the method, there is no step of drying the 18 F starting from a time when the eluting step is performed and ending at a time when the 18 F-labeling step is performed.