tert-butyl N-[(1S,2S)-1-benzyl-2-hydroxy-5-phenyl-4-thiazol-2-yl-pentyl]carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-[(1S,2S)-1-benzyl-2-hydroxy-5-phenyl-4-thiazol-2-yl-pentyl]carbamate
• 英文别名: tert-butyl N-[(2S,3S)-3-hydroxy-1,6-diphenyl-5-(1,3-thiazol-2-yl)hexan-2-yl]carbamate
• 化学式: C₂₆H₃₂N₂O₃S
• 分子量: 452.6
• InChiKey: PVPPHFPSWBSHQG-KXNJDZORSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  99.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Peptide isosteres containing a heterocycle useful in the treatment of alzheimer's disease
  申请人：Varghese John

  公开号：US20050159460A1

  公开（公告）日：2005-07-21

  The present invention relates to methods of treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of known compounds of formula (I) wherein R 1 , R 2 , R 3 , U′, U″, V, Y, W, Q, R′ are as defined herein.

  本发明涉及使用式(I)中已知化合物的方法，其中R1、R2、R3、U'、U"、V、Y、W、Q、R'的定义如本文所述，用于治疗阿尔茨海默病和其他疾病，和/或抑制β-分泌酶酶，和/或抑制哺乳动物中Aβ肽的沉积。
• PEPTIDE ISOTERS CONTAINING A HETEROCYCLE AS H.I.V. INHIBITORS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP0603309A1

  公开（公告）日：1994-06-29
• PEPTIDE ISOSTERES CONTAINING A HETEROCYCLE USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Elan Pharmaceuticals, Inc.

  公开号：EP1450795A1

  公开（公告）日：2004-09-01
• [EN] PEPTIDE ISOTERS CONTAINING A HETEROCYCLE AS H.I.V. INHIBITORS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：WO1993005026A1

  公开（公告）日：1993-03-18

  (EN) Novel compounds containing a heterocyclic isostere of formula (I) are disclosed, which inhibit the replication of the Human Immunodeficiency Virus.(FR) L'invention concerne de nouveaux composés contenant un isostère hétérocyclique de la formule (I), lesquels inhibent la réplication du virus de l'immunodéficience humaine.
• [EN] PEPTIDE ISOSTERES CONTAINING A HETEROCYCLE USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] ISOSTERES PEPTIDIQUES CONTENANT UN HETEROCYCLE QUI CONVIENT POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：ELAN PHARM INC

  公开号：WO2003047576A1

  公开（公告）日：2003-06-12

  The present invention relates to methods of treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of known compounds of formula (I) wherein R1, R2, R3, U' , U', V, Y, W, Q, R' are as defined herein.