Methyl 2,5-bis(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2,5-bis(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)benzoate
• 化学式: C₃₀H₅₆N₈O₂
• 分子量: 560.8
• InChiKey: ZRSLNKVAEMYCMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  105
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• METHOD FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS BY INHIBITION OF CXCR4/CXCL12 SIGNALING
  申请人：RAMOT AT TEL-AVIV UNIVERSITY LTD.

  公开号：US20160206592A1

  公开（公告）日：2016-07-21

  The present invention provides use of an inhibitor of G protein-coupled receptor CXCR4 for treating amyotrophic lateral sclerosis (ALS), for inhibiting glutamate release in astrocytes, or for increasing remyelinization in motor neurons.
• MODIFIED IMMUNE CELLS AND USES THEREOF
  申请人：ISI LIFE SCIENCE, INC.

  公开号：US20200297765A1

  公开（公告）日：2020-09-24

  Disclosed are modified T-cells so that the modified T-cells are capable of penetrating the fugetactic wall generated by tumors, including solid mass tumors, as well as imparting tumor specific targeting for these modified T-cells.