bis-[2-(N-iPr)aminoethyl]sulfide | 959670-52-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis-[2-(N-iPr)aminoethyl]sulfide
• 英文别名: Di(isopropylaminoethyl)sulfide；N-[2-[2-(propan-2-ylamino)ethylsulfanyl]ethyl]propan-2-amine
• CAS: 959670-52-1
• 化学式: C₁₀H₂₄N₂S
• 分子量: 204.38
• InChiKey: MPQQNSKIIYDJRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tin(ll) chloride 、 bis-[2-(N-iPr)aminoethyl]sulfide 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 以50%的产率得到5-thia-2,8-di-N-isopropyl-2,8-diaza-1-stanna(II)-bicyclo[3.3.0(1,5)]octane
  参考文献：
  名称：

  Tzschach, A.; Scheer, M.; Jurkschat, K., Zeitschrift fur Anorganische und Allgemeine Chemie

  摘要：

  DOI：
• 作为产物：
  描述：

  硫化碱 、 (2-chloro-ethyl)-isopropyl-amine 以43%的产率得到
  参考文献：
  名称：

  TZSCHACH, A.;SCHEER, M.;JURKSCHAT, K., Z. ANORG. UND ALLG. CHEM., 1984, 515, N 8, 147-150

  摘要：

  DOI：

文献信息

• Compositions and methods for the treatment of fungal infections
  申请人：Cellix Bio Private Limited

  公开号：US11220493B2

  公开（公告）日：2022-01-11

  The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII, formula VIII, formula IX or Formula X and, the methods for the treatment of fungal infections may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of fungal infections.

  本发明涉及这些化合物或其药用可接受的多晶型物、溶剂、对映体、立体异构体和水合物。包含有效量的式 I、式 II、式 III、式 IV、式 V、式 VI、式 VII、式 VIII、式 IX 或式 X 化合物的药物组合物以及治疗真菌感染的方法可配制成口服、口腔、直肠、局部、透皮、透粘膜、锭剂、喷雾剂、静脉注射、口服溶液、颊粘膜层片剂、肠外给药、糖浆或注射剂。此类组合物可用于治疗真菌感染。
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF FUNGAL INFECTIONS
  申请人：Cellix Bio Private Limited

  公开号：US20210053950A1

  公开（公告）日：2021-02-25

  The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII, formula VIII, formula IX or Formula X and, the methods for the treatment of fungal infections may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of fungal infections.
• OPHTHALMIC COMPOSITIONS AND METHODS FOR THE TREATMENT OF EYE DISORDERS
  申请人：Cellix Bio Private Limited

  公开号：US20210277050A1

  公开（公告）日：2021-09-09

  The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII, formula VIII, formula IX, formula X, formula XI formula XII, formula XIII, formula XIV, formula XV, formula XVI, or formula XVII and the methods for the treatment of eye diseases may be formulated for topical eye drop, topical paste, ocular solution, device-drug delivery, oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, nasal spray, oral solution, suspension, oral spray, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of glaucoma, presbyopia, IOP, cataract, dry eye and oGVHD.
• Tzschach, A.; Scheer, M.; Jurkschat, K., Zeitschrift fur Anorganische und Allgemeine Chemie
  作者：Tzschach, A.、Scheer, M.、Jurkschat, K.

  DOI：——

  日期：——
• TZSCHACH, A.;SCHEER, M.;JURKSCHAT, K., Z. ANORG. UND ALLG. CHEM., 1984, 515, N 8, 147-150
  作者：TZSCHACH, A.、SCHEER, M.、JURKSCHAT, K.

  DOI：——

  日期：——