(2R)-N-methyl-2-[(1-methyltetrazol-5-yl)sulfanylmethyl]-N-[(4-nitrophenyl)methyl]-4-oxo-azetidine-1-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (2R)-N-methyl-2-[(1-methyltetrazol-5-yl)sulfanylmethyl]-N-[(4-nitrophenyl)methyl]-4-oxo-azetidine-1-carboxamide
• 英文别名: (2R)-N-methyl-2-[(1-methyltetrazol-5-yl)sulfanylmethyl]-N-[(4-nitrophenyl)methyl]-4-oxoazetidine-1-carboxamide
• 化学式: C15H17N7O4S
• 分子量: 391.4
• InChiKey: ALNOVEJQPZGPMP-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  155
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• GENETIC SELECTION SYSTEM TO IDENTIFY PROTEASES, PROTEASE SUBSTRATES AND PROTEASE INHIBITORS
  申请人：Cottier Valerie

  公开号：US20090029369A1

  公开（公告）日：2009-01-29

  The present invention concerns a tester protein for identifying and/or monitoring protease activity in a cellular assay suitable for high throughput screenings by growth selection, wherein the tester polypeptide is a non-regulatory protein carrying a protease cleavage sequence. Upon co-expression of the protease recognizing said cleavage sequence the tester protein is inactivated, which influences the growth and/or survival of the host cells under the chosen conditions. However, in the presence of protease inhibitor the growth phenotype is reversed. The system can be used to identify proteases, protease inhibitors, and protease cleavage sites.