2-[(2-Carbamoyl-3-fluoro-phenyl)disulfanyl]-6-fluoro-benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(2-Carbamoyl-3-fluoro-phenyl)disulfanyl]-6-fluoro-benzamide
• 英文别名: 2-[(2-carbamoyl-3-fluorophenyl)disulfanyl]-6-fluorobenzamide
• 化学式: C₁₄H₁₀F₂N₂O₂S₂
• 分子量: 340.374
• InChiKey: CCJHSGLHVHPJLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  137
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-[(2-Carbonochloridoyl-3-fluorophenyl)disulfanyl]-6-fluorobenzoyl chloride 在 氨 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 生成 2-[(2-Carbamoyl-3-fluoro-phenyl)disulfanyl]-6-fluoro-benzamide
  参考文献：
  名称：

  Antimicrobial activity of fluorinated 1,2-benzisothiazol-3(2H)-ones and 2,2′-dithiobis(benzamides)

  摘要：

  Fluoro and trifluoromethyl derivatives of 1,2-benzisothiazol-3(2H)-ones and the 2,2'-dithiobis(benzamides) have been prepared and their antifungal and antibacterial activity evaluated. Several compounds were found highly active against fungi and Gram-positive microorganisms and a few derivatives displayed some activity against Gram-negative strains. Structure-activity relationships are proposed.

  DOI：

  10.1016/0223-5234(94)90132-5

文献信息

• Antimicrobial activity of fluorinated 1,2-benzisothiazol-3(2H)-ones and 2,2′-dithiobis(benzamides)
  作者：ML Carmellino、G Pagani、M Pregnolato、M Terreni、F Pastoni

  DOI：10.1016/0223-5234(94)90132-5

  日期：1994.1

  Fluoro and trifluoromethyl derivatives of 1,2-benzisothiazol-3(2H)-ones and the 2,2'-dithiobis(benzamides) have been prepared and their antifungal and antibacterial activity evaluated. Several compounds were found highly active against fungi and Gram-positive microorganisms and a few derivatives displayed some activity against Gram-negative strains. Structure-activity relationships are proposed.