(+/-)1,6-Diamino-octan | 102312-45-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (+/-)1,6-Diamino-octan
• 英文别名: 1-ethyl-hexanediyldiamine；1-Aethyl-hexandiyldiamin；1,6-Diaminooctane；octane-1,6-diamine
• CAS: 102312-45-8
• 化学式: C₈H₂₀N₂
• mdl: MFCD19204516
• 分子量: 144.26
• InChiKey: QAHWBDBQIHMPRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 镍 作用下， 生成 (+/-)1,6-Diamino-octan
  参考文献：
  名称：

  Charlish; Davies; Rose, Journal of the Chemical Society, 1948, p. 231

  摘要：

  DOI：

文献信息

• Notiz zur Darstellung aliphatischer Diamine
  作者：Giulio Vita、Giuseppe Bucher

  DOI：10.1002/cber.19660991045

  日期：1966.10

  No abstract is available for this article.

  本文没有摘要。
• Dendrimers as molecular translocators
  申请人：Goodman Murray

  公开号：US20060216265A1

  公开（公告）日：2006-09-28

  Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.

  转运分子包括一种树枝状聚合物和一种生物活性分子。这些转运分子的树枝状聚合物包括至少一个胍基团、至少一个质子化的胍基团、至少一个保护的胍基团、至少一个酰胺基团、至少一个质子化的酰胺基团、至少一个保护的酰胺基团、至少一个脲基团、至少一个质子化的脲基团、至少一个保护的脲基团、至少一个硫脲基团、至少一个质子化的硫脲基团，或至少一个保护的硫脲基团。生物活性分子与树枝状聚合物结合。一种增加药物生物利用度的方法包括将药物与本发明的树枝状聚合物结合。
• Dendrimers as Molecular Translocators
  申请人：Goodman Murray

  公开号：US20080221020A1

  公开（公告）日：2008-09-11

  Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.

  运输分子包括一个树状分子和一个生物活性分子。这种运输分子的树状分子包括至少一个鸟氨酸基团，至少一个质子化的鸟氨酸基团，至少一个保护的鸟氨酸基团，至少一个酰胺基团，至少一个质子化的酰胺基团，至少一个保护的酰胺基团，至少一个尿素基团，至少一个质子化的尿素基团，至少一个保护的尿素基团，至少一个硫脲基团，至少一个质子化的硫脲基团，或者至少一个保护的硫脲基团。生物活性分子与树状分子结合。一种增加药物生物利用度的方法包括将药物与本发明的树状分子结合。
• Neue Sulfonamide, ihre Herstellung und Verwendung als antimikrobielle Substanzen
  申请人：Henkel Kommanditgesellschaft auf Aktien

  公开号：EP0029974A1

  公开（公告）日：1981-06-10

  Sulfonamide der Formel werden durch Umsetzung entsprechender Aminoalkanole der Formel II mit einem Sulfonsäurechlorid der Formel R4-SO2Cl im Molverhältnis 1:1 bis 1:1,3 erhalten, wobei die bei der Reaktion entstehende Salzsäure neutralisiert wird. R' = Alkyl-(C1-18); R2 = H oder Alkyl-(C1-17) Summe der C-Atome in R1+R2 = 8-18; R3 = H, Alkyl-(C1-3), Hydroxyalkyl- (C2 oder 3), 2-(Dimethylamino)-ethyl- oder 3-(Dimethylamino)-propyl-, R4 = Alkyl-(C,-3), Phenyl- oder p-Tolyl-; m = 2-6; n = 0 oder 1. Die neuen Sulfonamide werden als antimikrobielle Wirkstoffe verwendet.

  式的磺酰胺 式 II 的相应氨基烷醇与式 R4-SO2Cl 的磺酸氯化物以 1:1 至 1:1.3 的摩尔比反应而得。 与式 R4-SO2Cl 的磺酰氯以 1:1 至 1:1.3 的摩尔比反应，从而中和反应过程中形成的盐酸。 R' = 烷基-(C1-18)；R2 = H 或烷基-(C1-17)；R1+R2 中 C 原子的总和 = 8-18；R3 = H、烷基-(C1-3)、羟基烷基-(C2 或 3)、2-(二甲基氨基)-乙基或 3-(二甲基氨基)-丙基；R4 = 烷基-(C,-3)、苯基或对甲苯基；m = 2-6；n = 0 或 1。 新型磺酰胺类化合物可用作抗菌剂。
• Ashless dispersants formed form substituted acylating agents and their production and use
  申请人：ETHYL PETROLEUM ADDITIVES, INC.

  公开号：EP0545653A1

  公开（公告）日：1993-06-09

  Succinic ester-amides are formed by (A) reacting (i) at least one substantially aliphatic polymer of at least one lower olefin, and (ii) an acidic reactant or a mixture of two or more acidic reactants represented by the general formula         R-CO-CH = CH-CO-R′ wherein R and R′ are independently -OH, -O-lower alkyl, a halogen atom, or taken together are a single oxygen atom; the process being characterized in that: a) the substantially aliphatic polymer is comprised predominantly or entirely of polyisobutene, at least 50% of the polyisobutene content of such polymer having an end group represented by the formula b) the mole ratio of said acidic reactant(s) : said polymer(s) is at least 1 : 1; c) the reaction mixture is maintained under superatmospheric pressure during at least a substantial portion of the reaction period; and d) said acylating agent is characterized by having an average total tar rating as determined by the method described in the specification hereof that is at least 25% lower than the average total tar rating of a corresponding product made in the same way under the same reaction conditions using a polyisobutene containing up to 10% of the above-depicted end group; and (B) reacting such acylating agent with at least one alcohol (preferably a polyhydric alcohol) and amine (preferably a polyamine having at least one primary amino group). Combinations of succinimides, succinic esters, and succinic ester-amides formed using such acylating agents are used in combination with other additives in forming lubricant compositions.

  琥珀酸酯酰胺是通过以下反应形成的：(A)(i)至少一种低级烯烃的实质上脂肪族聚合物，和(ii)一种酸性反应剂或两种或两种以上酸性反应剂的混合物，其通式为 R-CO-CH = CH-CO-R′ 其中 R 和 R′独立地为-OH、-O-低级烷基、卤素原子或合在一起为单个氧原子；该工艺的特征在于 a) 基本脂肪族聚合物主要或全部由聚异丁烯组成，该聚合物中至少 50% 的聚异丁烯含量具有由式表示的端基 b) 所述酸性反应剂与所述聚合物的摩尔比至少为 1:1； c) 至少在反应期间的大部分时间内，反应混合物保持在超大气压下；以及 d) 所述酰化剂的特点是，其平均总焦油等级（按本说明书所述方法测定）比在相同反应条件下用含有最多 10%上述端基的聚异丁烯以相同方法制得的相应产品的平均总焦油等级至少低 25%；以及 (A) 所述酸性反应剂与所述聚合物的摩尔比至少为 1:1。 (B) 使这种酰化剂与至少一种醇（最好是多羟基醇）和胺（最好是具有至少一个伯氨基 的多胺）反应。使用此类酰化剂形成的琥珀酰亚胺、琥珀酸酯和琥珀酸酯-酰胺组合可与其他添加剂一起用于形成润滑剂组合物。