2-(2,6-dichlorophenyl)-3-(4-methylpyrimidin-2-yl)-1,3-thiazolidine-4-thione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,6-dichlorophenyl)-3-(4-methylpyrimidin-2-yl)-1,3-thiazolidine-4-thione
• 英文别名: 2-(2,6-Dichlorophenyl)-3-(4-methylpyrimidin-2-yl)thiazolidine-4-thione
• 化学式: C₁₄H₁₁Cl₂N₃S₂
• 分子量: 356.299
• InChiKey: FYEPGVXDVLFKJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  86.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(2,6-Dichloro-phenyl)-3-(4-methyl-pyrimidin-2-yl)-thiazolidin-4-one 在 劳森试剂 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以81%的产率得到2-(2,6-dichlorophenyl)-3-(4-methylpyrimidin-2-yl)-1,3-thiazolidine-4-thione
  参考文献：
  名称：

  Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives

  摘要：

  Several 2,3-diaryl-1,3-thiazolidine-4-thione derivatives and 2,3-diaryl-1,3-thiazolidin-4-ones bearing a methyl group at C-5 position have been synthesized and tested as anti-HIV agents, The results of the in vitro tests showed that some of them proved to be effective inhibitors of HIV-1 replication. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

  DOI：

  10.1016/s0014-827x(02)01268-5

文献信息

• Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives
  作者：Angela Rao、Anna Carbone、Alba Chimirri、Erik De Clercq、Anna Maria Monforte、Pietro Monforte、Christophe Pannecouque、Maria Zappalà

  DOI：10.1016/s0014-827x(02)01268-5

  日期：2002.9

  Several 2,3-diaryl-1,3-thiazolidine-4-thione derivatives and 2,3-diaryl-1,3-thiazolidin-4-ones bearing a methyl group at C-5 position have been synthesized and tested as anti-HIV agents, The results of the in vitro tests showed that some of them proved to be effective inhibitors of HIV-1 replication. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.