1-phenylpropan-2-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-phenylpropan-2-amine
• 化学式: C18H26N2
• 分子量: 270.4
• InChiKey: PFOGAAASMPKKSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.15
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] 2,3,5 TRISUBSTITUTED ARYL AND HETEROARYL AMINO DERIVATIVES, COMPOSITIONS, AND METHODS OF USE<br/>[FR] DÉRIVÉS AMINÉS D'HÉTÉROARYLE ET D'ARYLE 2,3,5 TRISUBSTITUÉS, COMPOSITIONS ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：NEUROTHERAPEUTICS PHARMA INC

  公开号：WO2013059648A1

  公开（公告）日：2013-04-25

  Compounds are disclosed that have a formula represented by the following:(I) wherein Cy, L1 R1, R2a, R2b, R3, R4, n, and L2 are as described herein. These compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example addictive disorders, Alzheimer's Disease, anxiety disorders, ascites, autism, bipolar disorder, cancer, depression, endothelial corneal dystrophy, edema, epilepsy, glaucoma, Huntington's Disease, inflammatory pain, insomnia, ischemia, migraine, migraine with aura, migraine without aura, neuropathic pain, nociceptive neuralgia, nociceptive pain, ocular diseases, pain, itch, excessive itch, Pruritis, neuropathic pruritis, Parkinson's disease, personality disorders, postherpetic neuralgia, psychosis, schizophrenia, seizure disorders, tinnitus, and withdrawal syndromes.

  已披露具有以下表示的化合物的公式：(I)，其中Cy、L1、R1、R2a、R2b、R3、R4、n和L2如本文所述。这些化合物可以制备为药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的各种疾病，例如成瘾障碍、阿尔茨海默病、焦虑障碍、腹水、自闭症、躁郁症、癌症、抑郁症、内皮角膜营养不良、水肿、癫痫、青光眼、亨廷顿病、炎症性疼痛、失眠、缺血、偏头痛、伴有先兆的偏头痛、无先兆的偏头痛、神经病性疼痛、伤害性神经痛、伤害性疼痛、眼部疾病、疼痛、瘙痒、过度瘙痒、瘙痒、神经性瘙痒、帕金森病、人格障碍、带状疱疹后神经痛、精神病、精神分裂症、癫痫障碍、耳鸣和戒断综合症等。
• LC-MS configuration for purification and detection of analytes having a broad range of hydrophobicites
  申请人：COHESIVE TECHNOLOGIES INC.

  公开号：US10627374B2

  公开（公告）日：2020-04-21

  Systems, apparatuses, kits, and methods for purification and analysis of analytes having a broad range of hydrophobicities by liquid chromatography-mass spectrometry (LC-MS). Using one set of liquid chromatography columns, one set of mobile phase buffers, and, optionally, a single ionization method (e.g., electrospray ionization), a wide range of analytes can be purified and analyzed on a liquid chromatography-mass spectrometry (LC-MS) system. LC-MS purification and analysis of analytes having a broad range of partition coefficients is accomplished by selecting LC run parameters and MS system parameters that are particular to different classes of analytes without having to make column or buffer changes or any other hardware configuration changes to the LC-MS system. The methods, systems, and kits described herein provide for substantially increased speed/throughput and ease of use for a wide range analytes with essentially no compromise in specificity for individual analytes relative to previously described methods.

  利用液相色谱-质谱法（LC-MS）纯化和分析具有广泛疏水性的分析物的系统、装置、试剂盒和方法。使用一套液相色谱柱、一套流动相缓冲液以及可选的单一电离方法（如电喷雾电离），可在液相色谱-质谱联用系统上纯化和分析多种分析物。通过选择适用于不同类别分析物的液相色谱运行参数和质谱系统参数，可实现对具有广泛分配系数的分析物的液相色谱-质谱纯化和分析，而无需对液相色谱-质谱系统进行色谱柱或缓冲液更改或任何其他硬件配置更改。与之前描述的方法相比，本文描述的方法、系统和试剂盒大大提高了速度/通量，且易于使用，适用于多种分析物，对单个分析物的特异性基本上没有影响。
• LC-MS configuration for purification and detection of analytes having a broad range of hydrophobicities
  申请人：COHESIVE TECHNOLOGIES INC.

  公开号：US11333639B2

  公开（公告）日：2022-05-17

  Systems, apparatuses, kits, and methods for purification and analysis of analytes having a broad range of hydrophobicities by liquid chromatography-mass spectrometry (LC-MS). Using one set of liquid chromatography columns, one set of mobile phase buffers, and, optionally, a single ionization method (e.g., electrospray ionization), a wide range of analytes can be purified and analyzed on a liquid chromatography-mass spectrometry (LC-MS) system. LC-MS purification and analysis of analytes having a broad range of partition coefficients is accomplished by selecting LC run parameters and MS system parameters that are particular to different classes of analytes without having to make column or buffer changes or any other hardware configuration changes to the LC-MS system. The methods, systems, and kits described herein provide for substantially increased speed/throughput and ease of use for a wide range analytes with essentially no compromise in specificity for individual analytes relative to previously described methods.

  利用液相色谱-质谱法（LC-MS）纯化和分析具有广泛疏水性的分析物的系统、装置、试剂盒和方法。使用一套液相色谱柱、一套流动相缓冲液以及可选的单一电离方法（如电喷雾电离），可在液相色谱-质谱联用系统上纯化和分析多种分析物。通过选择适用于不同类别分析物的液相色谱运行参数和质谱系统参数，可实现对具有广泛分配系数的分析物的液相色谱-质谱纯化和分析，而无需对液相色谱-质谱系统进行色谱柱或缓冲液更改或任何其他硬件配置更改。与之前描述的方法相比，本文描述的方法、系统和试剂盒大大提高了速度/通量，且易于使用，适用于多种分析物，对单个分析物的特异性基本上没有影响。
• Prevention of development of dyskinesias
  申请人：——

  公开号：US20020115703A1

  公开（公告）日：2002-08-22

  The present invention relates to, among other things, a method for prevention or inhibition of the development of sensitization caused by the chronic use of dopaminergic agents with an alpha2-adrenoceptor antagonist or a pharmaceutically acceptable ester or salt thereof.

  本发明除其他外，涉及一种用α2-肾上腺素受体拮抗剂或其药学上可接受的酯或盐来预防或抑制因长期使用多巴胺能药物而引起的敏感化发展的方法。
• Compositions and methods for the treatment of disorders of the central and peripheral nervous systems
  申请人：Hochman W. Daryl

  公开号：US20060025387A1

  公开（公告）日：2006-02-02

  The present invention relates to methods and compositions for treating disorders of the central and/or peripheral nervous system by administering agents that are effective in reducing the effective amount, inactivating, and/or inhibiting the activity of a Na + —K + —2CT (NKCC) cotransporter. In certain embodiments, the Na + —K + —2Cl − co-transporter is NKCC1.

  本发明涉及治疗中枢和/或外周神经系统疾病的方法和组合物，其方法是施用能有效减少 Na + -K + -2CT（NKCC）共转运体的活性。在某些实施方案中，Na + -K + -2Cl - 共转运体是 NKCC1。