[5-(3,5-Dichlorophenyl)sulfanyl-4-[(3,4-difluorophenyl)methyl]-1-isopropyl-pyrazol-3-yl]methanol

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: [5-(3,5-Dichlorophenyl)sulfanyl-4-[(3,4-difluorophenyl)methyl]-1-isopropyl-pyrazol-3-yl]methanol
• 英文别名: [5-(3,5-dichlorophenyl)sulfanyl-4-[(3,4-difluorophenyl)methyl]-1-propan-2-ylpyrazol-3-yl]methanol
• 化学式: C₂₀H₁₈Cl₂F₂N₂OS
• 分子量: 443.3
• InChiKey: HLAIHUXWSCAYHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  63.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PYRAZOLE DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1401826B1

  公开（公告）日：2007-03-21
• US6538015B1
  申请人：——

  公开号：US6538015B1

  公开（公告）日：2003-03-25
• [EN] PYRAZOLE DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS<br/>[FR] DERIVES DE PYRAZOLE UTILISES COMME INHIBITEURS DE LA TRANSCRIPTASE INVERSE DU VIH
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002100853A1

  公开（公告）日：2002-12-19

  The invention is concerned with novel pyrazole derivatives, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds of formula I are inhibitos of the human immunodeficiency virus reverse transcriptase enzyme which is involved in viral replication. Consequently the compounds of this invention may be advantageously used as therapeutic agents for HIV mediated process. The invention describes novel compounds of formula I wherein R?1, R2, R3¿ and A are as defined in the description; ethers of compounds of formula I as well as pharmaceutically acceptable salts of the foregoing.