申请人:SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA
公开号:EP0789241A1
公开(公告)日:1997-08-13
The present invention relates to a serum or plasma separating composition comprising an oligomer of cyclopentadiene, an organic gelling agent and a dispersant for the organic gelling agent. The organic gelling agent is a condensation product of sorbitol and an aromatic aldehyde. The dispersant for the organic gelling agent is a polyoxyethylene-polyoxypropylene block copolymer having HLB of 1.0 to 9.0. The invention provides a serum or plasma separating composition which does not give out a bad smell by sterilization with radiation, has no influence derived from hemolysis, etc. on biochemical examination values of serum or plasma, does not cause phase separation of components, and is equal to the prior art in serum or plasma separating property, preservation stability, etc. Furthermore, the invention provides a serum or plasma separating composition which hardly brings about flow during preservation by standing in a horizontal lying position and hardly exhibits impaired invertibility with the lapse of time.
本发明涉及一种血清或血浆分离组合物,包括环戊二烯低聚物、有机胶凝剂和有机胶凝剂分散剂。有机胶凝剂是山梨醇和芳香醛的缩合产物。有机胶凝剂的分散剂是一种 HLB 值为 1.0 至 9.0 的聚氧乙烯-聚氧丙烯嵌段共聚物。本发明提供了一种血清或血浆分离组合物,该组合物通过辐射灭菌不会产生异味,不会因溶血等对血清或血浆的生化检查值产生影响,不会导致成分相分离,在血清或血浆分离性能、保存稳定性等方面与现有技术相同。此外,本发明还提供了一种血清或血浆分离组合物,该组合物在保存过程中以水平卧姿站立几乎不会产生流动,随着时间的推移也几乎不会表现出不可逆性。