N-(6-benzyl-5-methyl-7-oxo-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并嘧啶类
• 英文名称: N-(6-benzyl-5-methyl-7-oxo-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)acetamide
• 英文别名: N-(6-benzyl-5-methyl-7-oxo-1H-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)acetamide
• 化学式: C₁₅H₁₅N₅O₂
• 分子量: 297.31
• InChiKey: HYIDRMDEHIRZRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [1, 2, 4] Triazolo [1, 5-A] Pyrimidine Derivatives as Chromatographic Adsorbent for the Selective Adsorption of Igg
  申请人：Alterman Mathias

  公开号：US20080220968A1

  公开（公告）日：2008-09-11

  The present invention relates to a chromatographic adsorbent for selectively adsorbing IgG, comprising the following formula and its corresponding enol-form, wherein X represents O, S, or NH; R 1 represents H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 alkyl, Ar, —C(O)NHR 3 , —C(O)—R 3 or halo; R 2 represents H, C 1-3 alkyl or halo; R 3 represents H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 alkyl or Ar; n represents 0, 1, 2 or 3; Y represents a carrier. The present invention also relates to a method of producing said adsorbent as well as use thereof for separating substances by affinity chromatography.
• [1, 2, 4] TRIAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS CHROMATOGRAPHIC ADSORBENT FOR THE SELECTIVE ADSORPTION OF IGG
  申请人：ALTERMAN MATHIAS

  公开号：US20090259029A1

  公开（公告）日：2009-10-15

  The present invention relates to a chromatographic adsorbent for selectively adsorbing IgG, comprising the following formula and its corresponding enol-form, wherein X represents O, S, or NH; R 1 represents H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 alkyl, Ar, —C(O)NHR 3 , —C(O)—R 3 or halo; R 2 represents H, C 1-3 alkyl or halo; R 3 represents H, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 alkyl or Ar; n represents 0, 1, 2 or 3; Y represents a carrier. The present invention also relates to a method of producing said adsorbent as well as use thereof for separating substances by affinity chromatography.
• US7625838B2
  申请人：——

  公开号：US7625838B2

  公开（公告）日：2009-12-01
• [EN] [1, 2, 4] TRIAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS CHROMATOGRAPHIC ADSORBENT FOR THE SELCTIVE ADSORPTION OF IGG<br/>[FR] DERIVES DE [1, 2, 4] TRIAZOLO [1, 5-A] PYRIMIDINE UTILISES COMME ADSORBANTS CHROMATOGRAPHIQUES D'ADSORPTION SELECTIVE D'IGG
  申请人：GE HEALTHCARE BIO SCIENCES AB

  公开号：WO2007004954A1

  公开（公告）日：2007-01-11

  [EN] The present invention relates to a chromatographic adsorbent for selectively adsorbing IgG, comprising the following formula (I) and its corresponding enol-form, wherein X represents O, S, or NH; R¹ represents H, C_1-6 alkyl, C_1-6alkoxy, C_1-6 alkoxy-C_1-6 alkyl, Ar, -C(O)NHR³, -C(O)-R³ or halo; R² represents H, C_1-3 alkyl or halo; R³ represents H, C_1-6 alkyl, C_1-6 alkoxy, C_1-6 alkoxy-C_1-6alkyl or Ar; n represents 0, 1, 2 or 3; Y represents a carrier. The present invention also relates to a method of producing said adsorbent as well as use thereof for separating substances by affinity chromatography.
  [FR] La présente invention concerne un adsorbant chromatographique d'adsorption sélective d'IgG, comprenant la formule suivante (I) et sa forme énol correspondante, dans laquelle X représente O, S, ou NH; R¹ représente H, C_1-6 alkyle, C_1-6alkoxy, C_1-6 alkoxy-C_1-6alkyle, Ar, -C(O)NHR³, -C(O)-R³ ou halo; R² représente H, C_1-3 alkyle ou halo; R³ représente H, C_1-6 alkyle, C_1-6alkoxy, C_1-6 alkoxy-C_1-6alkyle ou Ar; n représente 0, 1, 2 ou 3; et Y représente un support. La présente invention concerne également une méthode de production dudit adorbant, ainsi que l'utilisation de celui-ci dans la séparation de substances par chromatographie d'affinité.