聚乙烯基邻苯二甲酸氢酯 | 29382-68-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 聚乙烯基邻苯二甲酸氢酯
• 英文名称: 2-[(Ethenyloxy)carbonyl]benzoic acid
• 英文别名: 2-ethenoxycarbonylbenzoic acid
• CAS: 29382-68-1
• 化学式: C₁₀H₈O₄
• 分子量: 192.17
• InChiKey: WWMQIJFJSHVMDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NITRILEOXIDE COMPOUND
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：US20180050983A1

  公开（公告）日：2018-02-22

  The present invention provides a compound of the formula (I): wherein, R 1 is a hydrogen atom or a hydrocarbon group; R 2 is —R 4 —R 5 ; R 3 is —R 4 —R 5 or —R 4 —R 6 ; R 4 is a divalent organic group; R 5 is OH, SH, COOH or NHR 9 ; R 9 is a hydrogen atom or an alkyl group having 1-6 carbon atoms; and R 6 is a hydrogen atom or an alkyl group having 1-6 carbon atoms.

  本发明提供了一种具有以下式（I）的化合物：其中，R1是氢原子或烃基；R2是—R4—R5；R3是—R4—R5或—R4—R6；R4是二价有机基；R5是OH、SH、COOH或NHR9；R9是氢原子或具有1-6个碳原子的烷基基团；R6是氢原子或具有1-6个碳原子的烷基基团。
• MULTIFUNCTIONAL NITRILEOXIDE COMPOUND
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：US20150251995A1

  公开（公告）日：2015-09-10

  The present invention provides a compound of the formula (I): wherein: R 2 and R 3 represent each independently a hydrogen atom or a hydrocarbon group; A represents an s-valent organic group; and s is an integer of 2-10. This nitrileoxide compound has stable and can be easily produced.

  本发明提供了一种化合物，其化学式为（I）：其中：R2和R3分别独立地代表氢原子或烃基；A代表s价有机基团；s为2-10的整数。这种腈氧化物化合物具有稳定性，且易于生产。
• NITRILE OXIDE COMPOUND
  申请人：Tokyo Institute Of Technology

  公开号：US20210078944A1

  公开（公告）日：2021-03-18

  The present invention provides a compound represented by formula (I) wherein symbols in the formula are as defined in the specification.

  本发明提供了一种由式（I）表示的化合物，其中式中的符号如规范中定义的那样。
• FLUORINE-CONTAINING NITRILE-OXIDE COMPOUND
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：US20160002153A1

  公开（公告）日：2016-01-07

  A stable and easily producible compound of the formula (I): wherein R 1 represents a hydrocarbon group; and R 2 and R 3 represent each independently a hydrogen atom or a hydrocarbon group: provided that in at least one of R 1 , R 2 and R 3 , at least one hydrogen atoms are substituted by a fluorine atom, and each of R 1 , R 2 and R 3 is attached via its carbon atom to a carbon atom to which a nitrileoxide group is attached.

  化合物的化学式为(I)，其中R1代表一个碳氢基团; R2和R3分别表示氢原子或碳氢基团，但至少在R1、R2和R3中的一个中，至少有一个氢原子被氟原子取代，而且R1、R2和R3中的每一个都通过其碳原子连接到一个腈氧化物基团的碳原子上。该化合物稳定且易于制备。
• PHARMACEUTICAL FORMULATION CONTAINING ANGIOTENSIN-II RECEPTOR BLOCKER
  申请人：Kim Sung Wuk

  公开号：US20110117194A1

  公开（公告）日：2011-05-19

  The present invention provides a pharmaceutical formulation containing an angiotensin-II receptor blocker and a release-control material as a pharmacologically active ingredient and a pharmaceutical formulation comprising an immediate-release compartment and an extended-release compartment. The immediate-release compartment contains an agent as a pharmacologically active ingredient for preventing and inhibiting hepatitis and the extended-release compartment has an angiotensin-II receptor blocker as a pharmacologically active ingredient. The formulation of the present invention maximizes the effectiveness on pharmacologically and clinically lowering blood pressure and preventing complications when taking the formulation, helps to avoid interaction with a drug which is metabolized by the same enzyme in the liver, and prevents and inhibits the incidence of drug-induced hepatitis which is caused by drug administration for a long time.

  本发明提供一种药物制剂，其包含一种血管紧张素II受体拮抗剂和一种释放控制材料作为药理活性成分，以及一种包括即时释放隔间和延时释放隔间的药物制剂。即时释放隔间含有一种药理活性成分，用于预防和抑制肝炎，而延时释放隔间则含有一种血管紧张素II受体拮抗剂作为药理活性成分。本发明的制剂在服用时最大程度地提高了药理和临床降低血压、预防并发症的有效性，有助于避免与同样在肝脏中代谢的药物发生相互作用，并预防和抑制由于长期用药引起的药物性肝炎的发生。