Benzyl-dimethyl-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]azanium;hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzyl-dimethyl-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]azanium;hydrochloride
• 化学式: C27H43ClNO2+
• mdl: MFCD00011742
• 分子量: 449.1
• InChiKey: UREZNYTWGJKWBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.37
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.555
• 拓扑面积：
  18.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• DISINFECTANT COMPOSITION FOR OPHTHALMIC USE
  申请人：Iromed Group S.r.l.

  公开号：EP3417847A1

  公开（公告）日：2018-12-26

  The present invention relates to a water-based disinfectant composition for use in the treatment and/or prevention of eye infections comprising at least one disinfectant selected from the group consisting of chlorhexidine, chlorhexidine salts, iodopovidone; vitamin E and/or derivatives thereof and hyaluronic acid and/or a salt thereof.

  本发明涉及一种用于治疗和/或预防眼部感染的水基消毒剂组合物，该组合物包含至少一种消毒剂，该消毒剂选自由洗必泰、洗必泰盐、碘伏酮、维生素 E 和/或其衍生物以及透明质酸和/或其盐组成的组。
• PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR INFLAMMATORY DISEASES WHICH CONTAINS PYRROLOPYRIMIDINE COMPOUND AS ACTIVE INGREDIENT
  申请人：Keio University

  公开号：EP3821893A1

  公开（公告）日：2021-05-19

  The present invention provides a prophylactic and/or therapeutic agent for inflammatory disease including a compound or a salt thereof, or a solvate thereof, the compound represented by a formula (1): [where each sign is defined as described in the description] as an active ingredient.

  本发明提供了一种预防和/或治疗炎症疾病的药物，包括由式（1）表示的化合物或其盐，或其溶液： [其中各符号的定义如说明书所述]作为活性成分。
• Cleaning composition and a method of making thereof
  申请人：——

  公开号：US20040162230A1

  公开（公告）日：2004-08-19

  A cleaning composition for treating and removing residue containing hydrocarbons and other flammable substances uses a mixture of one or more cleaning members containing quaternary salts, a chelator and a dispersant, mixed with water. The preferred cleaning members are tetradecyltrimethylammonium bromide, tetrasodium ethylenediaminetetraacetic acid, benzethonium hydrochloride and 2-butoxyethanol. The chelator is tetrasodium salt ethylenediamine of tetraacetic acid, and the dispersant is polyvinyl alcohol. Optionally, the cleaner contains ethanol and isopropyl alcohol.

  一种用于处理和清除含有碳氢化合物和其他易燃物质的残留物的清洗组合物，使用了一种或多种含有季盐、螯合剂和分散剂的清洗剂与水的混合物。首选的清洁剂是十四烷基三甲基溴化铵、乙二胺四乙酸四钠、盐酸苄索铵和 2-丁氧基乙醇。螯合剂为四乙酸乙二胺四钠盐，分散剂为聚乙烯醇。可选的是，清洁剂中含有乙醇和异丙醇。
• Stimulation of CPT-1 as a means to reduce weight
  申请人：Thupari N. Jagan

  公开号：US20050106217A1

  公开（公告）日：2005-05-19

  This invention provides methods and compositions for inducing weight loss and maintaining optimum weight comprising administering an agent that stimulates carnitine palmitoyl transferase-1 (CPT-1) activity to the patient in need, including human patients. These methods do not require inhibition of fatty acid synthesis. In particular, this invention provides methods for development of therapeutics that selectively enhance fatty acid oxidation, increase energy production, and reduce adiposity while preserving lean mass, through the pharmacological stimulation of CPT-1 activity. In a preferred mode, the agent is administered in an amount sufficient to increase fatty acid oxidation. In another preferred mode, the agent is administered in an amount sufficient to antagonize malonyl CoA inhibition of CPT-1. In yet another preferred mode, the agent is administered in an amount sufficient to increase malonyl CoA level.

  本发明提供了诱导减肥和维持最佳体重的方法和组合物，包括向需要的患者（包括人类患者）施用刺激肉碱棕榈酰转移酶-1（CPT-1）活性的制剂。这些方法不需要抑制脂肪酸的合成。特别是，本发明提供了通过药理学刺激 CPT-1 活性，选择性地增强脂肪酸氧化、增加能量产生、减少脂肪同时保持瘦肉质量的治疗药物的开发方法。在一种优选模式中，药剂的用量足以增加脂肪酸氧化。在另一种优选模式中，药剂的用量足以拮抗丙二酰 CoA 对 CPT-1 的抑制。在另一种优选模式中，药剂的用量足以提高丙二酰 CoA 的水平。
• Stimulation of cpt-1 as a means to reduce weight
  申请人：Thupari N Jagan

  公开号：US20050143467A1

  公开（公告）日：2005-06-30

  This invention provides methods and compositions for inducing weight loss and maintaining optimum weight comprising administering an agent that stimulates carnitine palmitoyl transferase-1 (CPT-1) activity to the patient in need, including human patients. These methods do not require inhibition of fatty acid synthesis. In particular, this invention provides methods for development of therapeutics that selectively enhance fatty acid oxidation, increase energy production, and reduce adiposity while preserving lean mass, through the pharmacological stimulation of CPT-1 activity. In a preferred mode, the agent is administered in an amount sufficient to increase fatty acid oxidation. In another preferred mode, the agent is administered in an amount sufficient to antagonize malonyl CoA inhibition of CPT-1. In yet another preferred mode, the agent is administered in an amount sufficient to increase malonyl CoA level.

  本发明提供了诱导减肥和维持最佳体重的方法和组合物，包括向需要的患者（包括人类患者）施用刺激肉碱棕榈酰转移酶-1（CPT-1）活性的制剂。这些方法不需要抑制脂肪酸的合成。特别是，本发明提供了通过药理学刺激 CPT-1 活性，选择性地增强脂肪酸氧化、增加能量产生、减少脂肪同时保持瘦肉质量的治疗药物的开发方法。在一种优选模式中，药剂的用量足以增加脂肪酸氧化。在另一种优选模式中，药剂的用量足以拮抗丙二酰 CoA 对 CPT-1 的抑制。在另一种优选模式中，药剂的用量足以提高丙二酰 CoA 的水平。