2'-Furyl-N-methylacetamid | 50618-94-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2'-Furyl-N-methylacetamid
• 英文别名: 2-furan-2-yl-N-methyl-acetamide；2-Furanacetamide, N-methyl-；2-(furan-2-yl)-N-methylacetamide
• CAS: 50618-94-5
• 化学式: C₇H₉NO₂
• mdl: MFCD19222340
• 分子量: 139.154
• InChiKey: RZXHHWSWAYUFTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PHENYL DERIVATIVES AND THEIR USE AS A MEDICAMENT
  申请人：Poitout Lydie

  公开号：US20100056507A1

  公开（公告）日：2010-03-04

  The present invention relates to new phenylic derivatives exhibiting a good affinity for certain sub-types of cannabinoid receptors, in particular the CB2 receptors. These derivatives are of particular interest in a method for treating pathological conditions and diseases in which one or more cannabinoid receptors are involved. The invention also relates to pharmaceutical compositions containing said new phenylic derivatives and to methods for the preparation and use thereof.

  本发明涉及新的苯基衍生物，具有良好的亲和力，特别是对CB2受体的某些亚型。这些衍生物在治疗涉及一个或多个大麻素受体的病理条件和疾病的方法中具有特殊的兴趣。本发明还涉及含有这些新的苯基衍生物的药物组合物，以及其制备和使用方法。
• TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP3016950B1

  公开（公告）日：2017-06-07
• US9663529B2
  申请人：——

  公开号：US9663529B2

  公开（公告）日：2017-05-30
• [EN] NOVEL [1,2,4]TRIAZOLO[4, 3-A]QUINOXALINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING BET PROTEIN-RELATED DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT<br/>[FR] NOUVEAU DÉRIVÉ DE [1,2,4]TRIAZOLO[4, 3-A]QUINOXALINE, SON PROCÉDÉ DE PRÉPARATION, ET COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES ASSOCIÉES À LA PROTÉINE BET, CONTENANT LEDIT DÉRIVÉ COMME PRINCIPE ACTIF<br/>[KO] 신규한 [1, 2, 4] 트리아졸로 [4, 3-A]퀴녹살린 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물
  申请人：DONG WHA PHARM CO LTD

  公开号：WO2018139876A1

  公开（公告）日：2018-08-02

  신규한 [1, 2, 4]트리아졸로[4, 3-a]퀴녹살린 유도체, 이들의 제조방법 및 이를 유효성분으로 함유하는 암 및 자가면역질환을 포함한 BET(Bromodomain Extra-terminal) 단백질 관련 질환의 예방 또는 치료용 약학적 조성물이 제공된다.