2-Methoxymethyl-2-methylpyrrolidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-Methoxymethyl-2-methylpyrrolidine
• 英文别名: 2-(methoxymethyl)-2-methylpyrrolidine
• 化学式: C₇H₁₅NO
• 分子量: 129.2
• InChiKey: DTELXVYYTBMURM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF
  申请人：ASTELLAS PHARMA INC.

  公开号：US20160002218A1

  公开（公告）日：2016-01-07

  [Problem] A compound which is useful as an active ingredient of a pharmaceutical composition for treating storage dysfunctions, voiding dysfunctions, and lower urinary tract diseases is provided. [Means for Solution] The present inventors have found that a thiazole derivative having pyrazine-2-carbonylamino substituted at the 2-position is an excellent muscarinic M 3 receptor positive allosteric modulator, and is useful as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M 3 receptor, thereby completing the present invention. The 2-acylaminothiazole derivative or a salt thereof of the present invention can be used as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M 3 receptor, for example, voiding dysfunctions such as underactive bladder.

  [问题]提供一种化合物，该化合物可用作治疗储存功能障碍、排尿功能障碍和下尿路疾病的药物组合物的活性成分。[解决方案]本发明人发现，在2位取代吡嗪-2-羧酰胺的噻唑衍生物是一种优秀的肌动蛋白M3受体正向变构调节剂，并且可用作预防和/或治疗与肌动蛋白M3受体引起的膀胱收缩有关的膀胱或尿路疾病的药物，从而完成了本发明。本发明的2-酰胺基噻唑衍生物或其盐可用作预防和/或治疗与肌动蛋白M3受体引起的膀胱收缩有关的膀胱或尿路疾病的药物，例如，排尿功能障碍，如无力膀胱。
• 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF
  申请人：Astellas Pharma Inc.

  公开号：EP2963036A1

  公开（公告）日：2016-01-06

  [Problem] A compound which is useful as an active ingredient of a pharmaceutical composition for treating storage dysfunctions, voiding dysfunctions, and lower urinary tract diseases is provided. [Means for Solution] The present inventors have found that a thiazole derivative having pyrazine-2-carbonylamino substituted at the 2-position is an excellent muscarinic M3 receptor positive allosteric modulator, and is useful as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M3 receptor, thereby completing the present invention. The 2-acylaminothiazole derivative or a salt thereof of the present invention can be used as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M3 receptor, for example, voiding dysfunctions such as underactive bladder.

  问题 本发明提供了一种化合物，该化合物可作为药物组合物的活性成分，用于治疗储尿功能障碍、排尿功能障碍和下尿路疾病。 [解决方法］ 本发明人发现，在 2-位上具有吡嗪-2-羰基氨基取代的噻唑衍生物是一种优良的毒蕈碱 M3 受体正异位调节剂，可用作预防和/或治疗与毒蕈碱 M3 受体引起的膀胱收缩有关的膀胱或尿路疾病的药物，从而完成了本发明。本发明的 2-酰氨基噻唑衍生物或其盐可用作预防和/或治疗与毒蕈碱类 M3 受体的膀胱收缩有关的膀胱或尿路疾病的药物，例如，排尿功能障碍，如膀胱功能不足。
• US9562044B2
  申请人：——

  公开号：US9562044B2

  公开（公告）日：2017-02-07