2-ethyl-3-methyl-1,3-oxazolidine | 1630-75-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 2-ethyl-3-methyl-1,3-oxazolidine
• 英文别名: 2-ethyl-3-methyloxazolidine；2-Ethyl-3-methyl-oxazolidin；Oxazolidine, 2-ethyl-3-methyl-
• CAS: 1630-75-7
• 化学式: C₆H₁₃NO
• 分子量: 115.175
• InChiKey: VXXYJCXKTXAVFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-ethyl-3-methyl-1,3-oxazolidine 在 高氯酸 作用下， 生成
  参考文献：
  名称：

  Schiff碱作为中间体在酸水溶液中水解2-烷基-3-甲基-1,3-恶唑烷的中间体

  摘要：

  已经在酸性溶液中分光光度法检查了2-烷基-3-甲基-1，3-恶唑烷水解的动力学。底物分解为2-甲基氨基乙醇和相应的醛已显示出是通过稳定的中间体进行的，该中间体在动力学和紫外光谱上与衍生自异丁醛和2-甲氧基乙基甲基胺的无环阳离子席夫氏碱非常相似。基于pH速率分布，活化参数，盐效应和溶剂氘同位素效应，对席夫碱中间体的形成和分解机理进行了讨论。

  DOI：

  10.1039/p29830001223
• 作为产物：
  描述：

  N-甲基-2-羟基乙胺 、 丙醛 生成 2-ethyl-3-methyl-1,3-oxazolidine
  参考文献：
  名称：

  Laurent,P.A.; do Carmo Ferreirade Almeida,R., Bulletin de la Societe Chimique de France, 1967, p. 570 - 571

  摘要：

  DOI：

文献信息

• Activated Polyoxazolines and Compositions Comprising the Same
  申请人：Harris J. Milton

  公开号：US20100069579A1

  公开（公告）日：2010-03-18

  The present disclosure provides terminally activated monofunctional POZ derivatives having a range of functional active groups allowing conjugation of the monofunctional POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed terminally activated monofunctional POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives.

  本公开提供了末端活化的单功能POZ衍生物，具有一系列功能活性基团，允许在广泛的反应条件下将单功能POZ衍生物与各种目标分子结合，从而产生水解稳定的目标分子-POZ结合物。此外，本公开提供了新的合成方法，用于制备所披露的末端活化的单功能POZ衍生物和使用所披露的末端活化的单功能POZ衍生物创建的水解稳定的目标分子-POZ结合物。
• Multi-Armed Forms of Activated Polyoxazoline and Methods of Synthesis Thereof
  申请人：Harris J. Milton

  公开号：US20100249368A1

  公开（公告）日：2010-09-30

  The present disclosure provides novel POZ-2 derivatives, methods for synthesizing POZ-2 derivatives and intermediates useful in such methods. In one embodiment, the POZ-2 derivative comprises two linear POZ chains of the present disclosure linked directly or indirectly to a branching moiety that contains a functional group for linking the POZ-2 derivative to the target molecule. Target molecule-POZ-2 conjugates are also described. In certain embodiment, the POZ-2 derivatives have low polydispersity values and a decreased amount of impurities produced by unwanted side reactions, such as, but not limited to, chain transfer.

  本公开提供了新型POZ-2衍生物，以及用于合成POZ-2衍生物和在这些方法中有用的中间体的方法。在一个实施例中，POZ-2衍生物包括两个线性POZ链，这些链直接或间接地连接到一个分支基团，该基团含有用于将POZ-2衍生物连接到目标分子的功能基团。还描述了目标分子-POZ-2共轭物。在某些实施例中，POZ-2衍生物具有低聚分散度值和减少不必要的副反应产生的杂质量，例如但不限于链转移。
• Activated polyoxazolines and conjugates and compositions comprising the same
  申请人：Serina Therapeutics, Inc.

  公开号：US10864276B2

  公开（公告）日：2020-12-15

  The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.

  本公开提供了具有一系列活性官能团的 POZ 衍生物，可在多种反应条件下将 POZ 衍生物与多种靶分子共轭，生成水解稳定的靶分子-POZ 共轭物。此外，本公开还为所公开的 POZ 衍生物和使用所公开的末端活化的单官能团 POZ 衍生物制备的水解稳定的靶分子-POZ 共轭物提供了新颖的合成方法。在一个实施方案中，POZ 衍生物是一种末端活化的单官能团 POZ 衍生物。
• Activated Polyoxazolines and Conjugates and Compositions Comprising the Same
  申请人：SERINA THERAPEUTICS, INC.

  公开号：US20170173171A1

  公开（公告）日：2017-06-22

  The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.
• ACTIVATED POLYOXAZOLINES AND CONJUGATES AND COMPOSITIONS COMPRISING THE SAME
  申请人：Serina Therapeutics, Inc.

  公开号：US20190070301A1

  公开（公告）日：2019-03-07

  The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.