Morpholine, 4-[3-(4-fluoro-3-nitrophenylsulfonyl)propyl]-

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Morpholine, 4-[3-(4-fluoro-3-nitrophenylsulfonyl)propyl]-
• 英文别名: 4-[3-(4-fluoro-3-nitrophenyl)sulfonylpropyl]morpholine
• 化学式: C13H17FN2O5S
• mdl: MFCD00740333
• 分子量: 332.35
• InChiKey: IEHAEFFWCRXYSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Methods and use of compounds that bind to RelA of NF-kB
  申请人：Cedars-Sinai Medical Center

  公开号：US10881641B2

  公开（公告）日：2021-01-05

  The invention provides methods and agents that modulate RelA activity. These methods and modulators of RelA activity can be used to treat cancer progression of basal-like breast cancer, such as triple-negative breast cancer.

  本发明提供了调节 RelA 活性的方法和制剂。 这些方法和 RelA 活性调节剂可用于治疗基底样乳腺癌（如三阴性乳腺癌）的癌症进展。
• METHODS AND USE OF COMPOUNDS THAT BIND TO RELA OF NF-KB
  申请人：Cedars-Sinai Medical Center

  公开号：US20180078528A1

  公开（公告）日：2018-03-22

  The invention provides methods and agents that modulate RelA activity. These methods and modulators of RelA activity can be used to treat cancer progression of basal-like breast cancer, such as triple-negative breast cancer.
• [EN] METHODS AND USE OF COMPOUNDS THAT BIND TO RELA OF NF-KB<br/>[FR] PROCÉDÉS ET UTILISATION DE COMPOSÉS QUI SE LIENT À RELA DE NF-KB
  申请人：CEDARS SINAI MEDICAL CENTER

  公开号：WO2016196664A1

  公开（公告）日：2016-12-08

  The invention provides methods and agents that modulate RelA activity. These methods and modulators of RelA acitivity can be used to treat cancer progression of basal-like breast cancer, such as triple-negative breast cancer.