1a,2,5,5Tetramethyl-trans-1a,4a,5,6,7,8-hexahydro-gamma-chromene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环化合物
• 英文名称: 1a,2,5,5Tetramethyl-trans-1a,4a,5,6,7,8-hexahydro-gamma-chromene
• 英文别名: 2,5,5,8a-tetramethyl-4a,6,7,8-tetrahydro-4H-chromene
• 化学式: C₁₃H₂₂O
• 分子量: 194.317
• InChiKey: ROBYDSVSLUQANR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  ethyl (4E)-2-acetyl-2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5,9-dimethyldeca-4,8-dienoate 在 aluminum (III) chloride 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以48%的产率得到1a,2,5,5Tetramethyl-trans-1a,4a,5,6,7,8-hexahydro-gamma-chromene
  参考文献：
  名称：

  New chemical access for pyran core embedded derivatives from bisalkenylated 1,3-diketones and 1,3-diketoesters via tandem C-dealkenylation and cyclization

  摘要：

  New chemical access has been developed for the synthesis of pyran core embedded derivatives from 1,3-diketones and 1,3-diketoesters, in which the active methylene group of 1,3-diketone or 1,3-diketoester was alkenylated with three equivalents of alkenyl bromides in presence NaH to give bisalkenyl 1,3-diketones or 1,3-diketoesters and the resultant bisalkenyl 1,3-diketones or 1,3-diketoesters were reacted with AlCl3 at room temperature to furnish pyran core embedded derivatives in good to excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.030

文献信息

• New chemical access for pyran core embedded derivatives from bisalkenylated 1,3-diketones and 1,3-diketoesters via tandem C-dealkenylation and cyclization
  作者：T. Narender、S. Sarkar、K. Venkateswarlu、J.K. Kumar

  DOI：10.1016/j.tetlet.2010.10.030

  日期：2010.12

  New chemical access has been developed for the synthesis of pyran core embedded derivatives from 1,3-diketones and 1,3-diketoesters, in which the active methylene group of 1,3-diketone or 1,3-diketoester was alkenylated with three equivalents of alkenyl bromides in presence NaH to give bisalkenyl 1,3-diketones or 1,3-diketoesters and the resultant bisalkenyl 1,3-diketones or 1,3-diketoesters were reacted with AlCl3 at room temperature to furnish pyran core embedded derivatives in good to excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.